Reactome | RUNX1 binds to TNFRSF18 (GITR) gene promoter and intron 1

Schema > Reaction > Entries

authored	[InstanceEdit:8938982] Orlic-Milacic, Marija, 2016-09-14
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:8877486] Orlic-Milacic, Marija, 2016-06-22
dbId	8877485
displayName	RUNX1 binds to TNFRSF18 (GITR) gene promoter and intron 1
edited	[InstanceEdit:9005626] Orlic-Milacic, Marija, 2017-05-09
eventOf	[Pathway:R-HSA-8877330] RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-8877493] TNFRSF18 (GITR) gene expression is stimulated by FOXP3 and inhibited by RUNX1 - Homo sapiens
input	[Complex:R-HSA-8865330] RUNX1:CBFB [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-8877484] TNFRSF18 gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8877190] Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	RUNX1 binds to TNFRSF18 (GITR) gene promoter and intron 1
output	[Complex:R-HSA-8877483] RUNX1:CBFB:TNFRSF18 gene [nucleoplasm]
precedingEvent	[Reaction:R-HSA-8865320] CBFB binds RUNX1 - Homo sapiens
releaseDate	2017-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9005627] Ito, Yoshiaki, 2016-12-20 [InstanceEdit:9005628] Chuang, Linda Shyue Huey, 2016-12-20
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8877485
summation	[Summation:8877481] The RUNX1:CBFB complex binds to the promoter and the first i...

(precedingEvent)	[BlackBoxEvent:R-HSA-8877493] TNFRSF18 (GITR) gene expression is stimulated by FOXP3 and inhibited by RUNX1
(hasEvent)	[Pathway:R-HSA-8877330] RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)

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