Reactome | RUNX1:CBFB:KMT2A [nucleoplasm]

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RUNX1:CBFB:KMT2A [nucleoplasm] Show undefined attributes

compartment	[Compartment:7660] nucleoplasm
componentOf	[Complex:R-HSA-8865490] RUNX1:CBFB:KMT2A:SPI1 gene:Nucleosome [nucleoplasm] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-8865491] RUNX1:CBFB:KMT2A binds SPI1 (PU.1) gene - Homo sapiens
created	[InstanceEdit:8865475] Orlic-Milacic, Marija, 2016-03-22
dbId	8865480
displayName	RUNX1:CBFB:KMT2A [nucleoplasm]
hasComponent	[EntityWithAccessionedSequence:R-HSA-1183223] KMT2A [nucleoplasm] [Complex:R-HSA-8865330] RUNX1:CBFB [nucleoplasm]
inDisease	false
inferredTo	[Complex:R-MMU-8865480] RUNX1:CBFB:KMT2A [nucleoplasm] - Mus musculus [Complex:R-RNO-8865480] RUNX1:CBFB:KMT2A [nucleoplasm] - Rattus norvegicus [Complex:R-CFA-8865480] RUNX1:CBFB:KMT2A [nucleoplasm] - Canis familiaris [Complex:R-BTA-8865480] RUNX1:CBFB:KMT2A [nucleoplasm] - Bos taurus [Complex:R-SSC-8865480] RUNX1:CBFB:KMT2A [nucleoplasm] - Sus scrofa [Complex:R-DRE-8865480] RUNX1:CBFB:KMT2A [nucleoplasm] - Danio rerio [Complex:R-XTR-8865480] RUNX1:CBFB:KMT2A [nucleoplasm] - Xenopus tropicalis [Complex:R-GGA-8865480] RUNX1:CBFB:KMT2A [nucleoplasm] - Gallus gallus [Complex:R-DME-8865480] RUNX1:CBFB:KMT2A [nucleoplasm] - Drosophila melanogaster
isChimeric	false
literatureReference	[LiteratureReference:8865478] The ability of MLL to bind RUNX1 and methylate H3K4 at PU.1 regulatory regions is impaired by MDS/AML-associated RUNX1/AML1 mutations
maxDepth	3
modified	[InstanceEdit:8955517] Orlic-Milacic, Marija, 2017-01-11
name	RUNX1:CBFB:KMT2A
producedByEvent	[Reaction:R-HSA-8865482] KMT2A (MLL) binds RUNX1 - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-8865480

Referrals

(input)	[Reaction:R-HSA-8865491] RUNX1:CBFB:KMT2A binds SPI1 (PU.1) gene
(hasComponent)	[Complex:R-HSA-8865490] RUNX1:CBFB:KMT2A:SPI1 gene:Nucleosome [nucleoplasm] [Complex:R-HSA-8865496] RUNX1:CBFB:KMT2A:SPI1 gene:H3K4me3-Nucleosome [nucleoplasm]
(activeUnit)	[PositiveRegulation:R-HSA-8865504] Positive regulation by 'RUNX1:CBFB:KMT2A:SPI1 gene:H3K4me3-Nucleosome [nucleoplasm]'
(output)	[Reaction:R-HSA-8865482] KMT2A (MLL) binds RUNX1

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