Reactome | RUNX1 binds PRMT1

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RUNX1 binds PRMT1 Show undefined attributes

authored	[InstanceEdit:8938982] Orlic-Milacic, Marija, 2016-09-14
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:8934739] Orlic-Milacic, Marija, 2016-08-11
dbId	8934742
displayName	RUNX1 binds PRMT1
edited	[InstanceEdit:9005626] Orlic-Milacic, Marija, 2017-05-09
eventOf	[Pathway:R-HSA-8936459] RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function - Homo sapiens
followingEvent	[Reaction:R-HSA-8934735] PRMT1 arginine-methylates RUNX1 - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-3215140] PRMT1 [nucleoplasm] [Complex:R-HSA-8865330] RUNX1:CBFB [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8934723] Methylation of RUNX1 by PRMT1 abrogates SIN3A binding and potentiates its transcriptional activity
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	RUNX1 binds PRMT1
orthologousEvent	[Reaction:R-CEL-8934742] RUNX1 binds PRMT1 - Caenorhabditis elegans [Reaction:R-DME-8934742] RUNX1 binds PRMT1 - Drosophila melanogaster [Reaction:R-XTR-8934742] RUNX1 binds PRMT1 - Xenopus tropicalis [Reaction:R-DRE-8934742] RUNX1 binds PRMT1 - Danio rerio [Reaction:R-SSC-8934742] RUNX1 binds PRMT1 - Sus scrofa [Reaction:R-BTA-8934742] RUNX1 binds PRMT1 - Bos taurus [Reaction:R-CFA-8934742] RUNX1 binds PRMT1 - Canis familiaris [Reaction:R-RNO-8934742] RUNX1 binds PRMT1 - Rattus norvegicus [Reaction:R-MMU-8934742] RUNX1 binds PRMT1 - Mus musculus
output	[Complex:R-HSA-8934741] RUNX1:CBFB:PRMT1 [nucleoplasm]
precedingEvent	[Reaction:R-HSA-8865320] CBFB binds RUNX1 - Homo sapiens
releaseDate	2017-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9005627] Ito, Yoshiaki, 2016-12-20 [InstanceEdit:9005628] Chuang, Linda Shyue Huey, 2016-12-20
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8934742
summation	[Summation:8934740] RUNX1 forms a complex with protein arginine methyltransferas...

Referrals

(hasEvent)	[Pathway:R-HSA-8936459] RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
(precedingEvent)	[Reaction:R-HSA-8934735] PRMT1 arginine-methylates RUNX1