Reactome | RUNX1 [nucleoplasm]

compartment	[Compartment:7660] nucleoplasm
componentOf	[Complex:R-HSA-8938885] RUNX1:PML [nucleoplasm] - Homo sapiens [Complex:R-HSA-9942724] TBX21:RUNX1 [nucleoplasm] - Homo sapiens [Complex:R-HSA-9616212] CEBPA gene:RUNX1:SPI1:GATA2:TAL1:FLI1:MYB [nucleoplasm] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-8938867] CCND3,(CCND1,CCND2) binds RUNX1 - Homo sapiens [Reaction:R-HSA-8938887] PML binds RUNX1 - Homo sapiens [Reaction:R-HSA-9604703] RUNX1 binds NOTCH4 gene - Homo sapiens [Reaction:R-HSA-9616214] RUNX1, SPI1 (PU.1), GATA2, TAL1 (SCL), FLI1, and MYB bind the CEBPA promoter - Homo sapiens [Reaction:R-HSA-9942757] TBX21 binds RUNX1 - Homo sapiens [Reaction:R-HSA-9731051] SARS-CoV-1 3b binds to RUNX1 - Homo sapiens [Reaction:R-HSA-8937682] RUNX1 binds SRC - Homo sapiens [Reaction:R-HSA-8865320] CBFB binds RUNX1 - Homo sapiens
created	[InstanceEdit:8865296] Orlic-Milacic, Marija, 2016-03-21
dbId	8865295
displayName	RUNX1 [nucleoplasm]
endCoordinate	453
inDisease	false
inferredTo	[EntityWithAccessionedSequence:R-MMU-8865295] RUNX1 [nucleoplasm] - Mus musculus [EntityWithAccessionedSequence:R-RNO-8865295] RUNX1 [nucleoplasm] - Rattus norvegicus [EntityWithAccessionedSequence:R-CFA-8865295] RUNX1 [nucleoplasm] - Canis familiaris [EntityWithAccessionedSequence:R-BTA-8865295] RUNX1 [nucleoplasm] - Bos taurus [EntityWithAccessionedSequence:R-SSC-8865295] RUNX1 [nucleoplasm] - Sus scrofa [EntityWithAccessionedSequence:R-DRE-8865295] RUNX1 [nucleoplasm] - Danio rerio [EntityWithAccessionedSequence:R-XTR-8865295] RUNX1 [nucleoplasm] - Xenopus tropicalis [EntityWithAccessionedSequence:R-GGA-8865295] RUNX1 [nucleoplasm] - Gallus gallus [EntityWithAccessionedSequence:R-DME-8865295] RunxA [nucleoplasm] - Drosophila melanogaster [EntityWithAccessionedSequence:R-DME-8865295-2] run [nucleoplasm] - Drosophila melanogaster [EntityWithAccessionedSequence:R-DME-8865295-3] RunxB [nucleoplasm] - Drosophila melanogaster [EntityWithAccessionedSequence:R-DME-8865295-4] lz [nucleoplasm] - Drosophila melanogaster [DefinedSet:R-DME-8865295-5] Homologues of RUNX1 [nucleoplasm] - Drosophila melanogaster [EntityWithAccessionedSequence:R-CEL-8865295] RUNX1 [nucleoplasm] - Caenorhabditis elegans
maxDepth	1
memberOf	[DefinedSet:R-HSA-8938850] RUNX1,RUNX1:CBFB [nucleoplasm] - Homo sapiens
modified	[InstanceEdit:8879177] Wu, G, 2016-07-15
name	RUNX1 Runt-related transcription factor 1 AML1 Oncogene AML-1 Acute myeloid leukemia 1 protein Core-binding factor subunit alpha-2 CBF-alpha-2 CBFA2 Polyomavirus enhancer-binding protein 2 alpha B subunit PEA2-alpha B PEBP2-alpha B SL3-3 enhancer factor 1 alpha B subunit SL3/AKV core-binding factor alpha B subunit RUNX1_HUMAN
producedByEvent	[Reaction:R-HSA-8937767] PTPN11 dephosphorylates RUNX1 - Homo sapiens [BlackBoxEvent:R-HSA-8935785] RUNX1 mRNA translation is inhibited by miR-17, miR-18a, miR-20a, miR-27a, miR-106a, miR-215, miR-302b, miR-378 and miR-675 - Homo sapiens
referenceEntity	[ReferenceGeneProduct:uniprot:Q01196] UniProt:Q01196 RUNX1
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-8865295
startCoordinate	1

(hasComponent)	[Complex:R-HSA-9616212] CEBPA gene:RUNX1:SPI1:GATA2:TAL1:FLI1:MYB [nucleoplasm] [Complex:R-HSA-9942724] TBX21:RUNX1 [nucleoplasm] [Complex:R-HSA-9731008] RUNX1:3b [nucleoplasm] [Complex:R-HSA-8938885] RUNX1:PML [nucleoplasm] [Complex:R-HSA-8937687] p-Y419-SRC:RUNX1 [nucleoplasm] [Complex:R-NUL-8865511] RUNX1:Cbfb [nucleoplasm] [Complex:R-HSA-8938868] RUNX1:CCND3,(CCND1,CCND2) [nucleoplasm] [Complex:R-HSA-8865330] RUNX1:CBFB [nucleoplasm] [Complex:R-HSA-9604705] RUNX1:NOTCH4 gene [nucleoplasm]
(input)	[Reaction:R-HSA-9616214] RUNX1, SPI1 (PU.1), GATA2, TAL1 (SCL), FLI1, and MYB bind the CEBPA promoter [Reaction:R-HSA-9942757] TBX21 binds RUNX1 [Reaction:R-HSA-9731051] SARS-CoV-1 3b binds to RUNX1 [Reaction:R-HSA-8938867] CCND3,(CCND1,CCND2) binds RUNX1 [Reaction:R-HSA-8938887] PML binds RUNX1 [Reaction:R-HSA-8937682] RUNX1 binds SRC [Reaction:R-HSA-8865320] CBFB binds RUNX1 [Reaction:R-HSA-9604703] RUNX1 binds NOTCH4 gene
(output)	[Reaction:R-HSA-8937767] PTPN11 dephosphorylates RUNX1 [BlackBoxEvent:R-HSA-8935785] RUNX1 mRNA translation is inhibited by miR-17, miR-18a, miR-20a, miR-27a, miR-106a, miR-215, miR-302b, miR-378 and miR-675
(hasMember)	[DefinedSet:R-HSA-8938850] RUNX1,RUNX1:CBFB [nucleoplasm]
(activeUnit)	[NegativeGeneExpressionRegulation:9604723] Negative gene expression regulation by 'RUNX1:NOTCH4 gene [nucleoplasm]'

RUNX1 [nucleoplasm] Show undefined attributes

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