Reactome | Clathrin-mediated endocytosis

Schema > Pathway > Entries

Clathrin-mediated endocytosis Show undefined attributes

authored	[InstanceEdit:8870660] Rothfels, Karen, 2016-05-10
created	[InstanceEdit:8856829] Rothfels, Karen, 2016-02-11
dbId	8856828
displayName	Clathrin-mediated endocytosis
doi	10.3180/R-HSA-8856828.1
edited	[InstanceEdit:8870660] Rothfels, Karen, 2016-05-10
eventOf	[Pathway:R-HSA-199991] Membrane Trafficking - Homo sapiens
hasDiagram	true
hasEHLD	false
hasEvent	[Pathway:R-HSA-8856825] Cargo recognition for clathrin-mediated endocytosis - Homo sapiens [Reaction:R-HSA-8871196] Initial binding of AP-2 and clathrin to PI(4,5)P2 - Homo sapiens [Reaction:R-HSA-8862280] FCHo proteins bind nascent clathrin-coated pit - Homo sapiens [Reaction:R-HSA-8856808] Recruitment of AP-2 complex and clathrin - Homo sapiens [Reaction:R-HSA-8868066] PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 - Homo sapiens [Reaction:R-HSA-8856813] AAK1 phosphorylates AP-2 mu subunit at T156 - Homo sapiens [Reaction:R-HSA-8867756] CLASP proteins and cargo are recruited to the nascent clathrin-coated pit - Homo sapiens [Reaction:R-HSA-8868071] Clathrin recruits PIK3C2A - Homo sapiens [Reaction:R-HSA-8868072] Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 - Homo sapiens [Reaction:R-HSA-8867754] F- and N- BAR domain proteins bind the clathrin-coated pit - Homo sapiens [Reaction:R-HSA-8868230] SNX9 recruits components of the actin polymerizing machinery - Homo sapiens [Reaction:R-HSA-8868236] BAR domain proteins recruit dynamin - Homo sapiens [Reaction:R-HSA-8868651] Endophilins recruit synaptojanins to the clathrin-coated pit - Homo sapiens [Reaction:R-HSA-8868648] SYNJ hydrolyze PI(4,5)P2 to PI(4)P - Homo sapiens [Reaction:R-HSA-8868661] Dynamin-mediated GTP hydrolysis promotes vesicle scission - Homo sapiens [Reaction:R-HSA-8868659] Clathrin recruits auxilins to the clathrin-coated vesicle - Homo sapiens [Reaction:R-HSA-8868660] Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle - Homo sapiens [Reaction:R-HSA-8868658] HSPA8-mediated ATP hydrolysis promotes vesicle uncoating - Homo sapiens [Reaction:R-HSA-8871194] RAB5 and GAPVD1 bind AP-2 - Homo sapiens [BlackBoxEvent:R-HSA-8871193] Dissociation of AAK1 and dephosphorylation of AP-2 mu2 - Homo sapiens [BlackBoxEvent:R-HSA-8869438] Dissociation of clathrin-associated proteins - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8868702] Coated vesicles from pig brain: purification and biochemical characterization [LiteratureReference:8856466] Forty Years of Clathrin-coated Vesicles [LiteratureReference:8856473] Molecular mechanism and physiological functions of clathrin-mediated endocytosis [LiteratureReference:8867692] Molecular structure, function, and dynamics of clathrin-mediated membrane traffic [LiteratureReference:8870594] Endocytosis of receptor tyrosine kinases [LiteratureReference:8870614] ?-Arrestin drives MAP kinase signalling from clathrin-coated structures after GPCR dissociation [LiteratureReference:8870599] Epidermal growth factor-stimulated Akt phosphorylation requires clathrin or ErbB2 but not receptor endocytosis [LiteratureReference:8870570] Control of EGF receptor signaling by clathrin-mediated endocytosis [LiteratureReference:8870585] Endocytosis and signalling: intertwining molecular networks [LiteratureReference:8870597] Endocytosis, signaling, and beyond [LiteratureReference:8870584] Endocytic control of signaling at the plasma membrane [LiteratureReference:8868162] A high precision survey of the molecular dynamics of mammalian clathrin-mediated endocytosis [LiteratureReference:8868489] Phosphatidylinositol-(4,5)-bisphosphate regulates clathrin-coated pit initiation, stabilization, and size [LiteratureReference:8864622] Cargo recognition in clathrin-mediated endocytosis [LiteratureReference:8863700] Role of the AP2 beta-appendage hub in recruiting partners for clathrin-coated vesicle assembly [LiteratureReference:8864680] Molecular switches involving the AP-2 beta2 appendage regulate endocytic cargo selection and clathrin coat assembly [LiteratureReference:8870608] The emerging role of phosphoinositide clustering in intracellular trafficking and signal transduction [LiteratureReference:8867983] BAR domain scaffolds in dynamin-mediated membrane fission [LiteratureReference:8870575] Curvature of clathrin-coated pits driven by epsin [LiteratureReference:8870588] Endocytosis by random initiation and stabilization of clathrin-coated pits [LiteratureReference:8867678] Cargo and dynamin regulate clathrin-coated pit maturation [LiteratureReference:8870606] Measuring the hierarchy of molecular events during clathrin-mediated endocytosis [LiteratureReference:8870569] Advances in analysis of low signal-to-noise images link dynamin and AP2 to the functions of an endocytic checkpoint [LiteratureReference:8867689] Endocytic accessory proteins are functionally distinguished by their differential effects on the maturation of clathrin-coated pits [LiteratureReference:8868294] Dynamin, a membrane-remodelling GTPase [LiteratureReference:8868303] Eps15 and Dap160 control synaptic vesicle membrane retrieval and synapse development [LiteratureReference:8868197] SNX9 - a prelude to vesicle release [LiteratureReference:8867997] SNX9 regulates dynamin assembly and is required for efficient clathrin-mediated endocytosis [LiteratureReference:8868272] A role of amphiphysin in synaptic vesicle endocytosis suggested by its binding to dynamin in nerve terminals [LiteratureReference:8868281] Crystal structure of the amphiphysin-2 SH3 domain and its role in the prevention of dynamin ring formation [LiteratureReference:8868310] Synaptic vesicle endocytosis impaired by disruption of dynamin-SH3 domain interactions [LiteratureReference:8868183] Coordinated actions of actin and BAR proteins upstream of dynamin at endocytic clathrin-coated pits [LiteratureReference:8868016] Spatiotemporal control of endocytosis by phosphatidylinositol-3,4-bisphosphate [LiteratureReference:8868308] G domain dimerization controls dynamin's assembly-stimulated GTPase activity [LiteratureReference:8870580] Dissecting dynamin's role in clathrin-mediated endocytosis [LiteratureReference:8868543] The role of molecular chaperones in clathrin mediated vesicular trafficking
modified	[InstanceEdit:10931649] Wright, Adam, 2024-03-08
name	Clathrin-mediated endocytosis
orthologousEvent	[Pathway:R-MMU-8856828] Clathrin-mediated endocytosis - Mus musculus [Pathway:R-RNO-8856828] Clathrin-mediated endocytosis - Rattus norvegicus [Pathway:R-CFA-8856828] Clathrin-mediated endocytosis - Canis familiaris [Pathway:R-BTA-8856828] Clathrin-mediated endocytosis - Bos taurus [Pathway:R-SSC-8856828] Clathrin-mediated endocytosis - Sus scrofa [Pathway:R-DRE-8856828] Clathrin-mediated endocytosis - Danio rerio [Pathway:R-XTR-8856828] Clathrin-mediated endocytosis - Xenopus tropicalis [Pathway:R-GGA-8856828] Clathrin-mediated endocytosis - Gallus gallus [Pathway:R-DME-8856828] Clathrin-mediated endocytosis - Drosophila melanogaster [Pathway:R-CEL-8856828] Clathrin-mediated endocytosis - Caenorhabditis elegans [Pathway:R-DDI-8856828] Clathrin-mediated endocytosis - Dictyostelium discoideum [Pathway:R-SPO-8856828] Clathrin-mediated endocytosis - Schizosaccharomyces pombe [Pathway:R-SCE-8856828] Clathrin-mediated endocytosis - Saccharomyces cerevisiae [Pathway:R-PFA-8856828] Clathrin-mediated endocytosis - Plasmodium falciparum
releaseDate	2016-06-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8870617] Antonescu, Costin N, 2016-05-10
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-8856828
summation	[Summation:8868709] Clathrin-mediated endocytosis (CME) is one of a number of pr...

Referrals

(hasEvent)	[Pathway:R-HSA-199991] Membrane Trafficking
(hasEncapsulatedEvent)	[Pathway:R-HSA-8856825] Cargo recognition for clathrin-mediated endocytosis

Cite Us!