Reactome | Clathrin-mediated endocytosis

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Clathrin-mediated endocytosis Show undefined attributes

created	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
dbId	11050696
displayName	Clathrin-mediated endocytosis
eventOf	[Pathway:R-DDI-199991] Membrane Trafficking - Dictyostelium discoideum
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	true
hasEHLD	false
hasEvent	[Pathway:R-DDI-8856825] Cargo recognition for clathrin-mediated endocytosis - Dictyostelium discoideum [Reaction:R-DDI-8871196] Initial binding of AP-2 and clathrin to PI(4,5)P2 - Dictyostelium discoideum [Reaction:R-DDI-8868066] PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 - Dictyostelium discoideum [Reaction:R-DDI-8856813] AAK1 phosphorylates AP-2 mu subunit at T156 - Dictyostelium discoideum
inferredFrom	[Pathway:R-HSA-8856828] Clathrin-mediated endocytosis - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	3
name	Clathrin-mediated endocytosis
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:170941] Dictyostelium discoideum
stId	R-DDI-8856828
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DDI-199991] Membrane Trafficking
(hasEncapsulatedEvent)	[Pathway:R-DDI-8856825] Cargo recognition for clathrin-mediated endocytosis
(inferredTo)	[Pathway:R-HSA-8856828] Clathrin-mediated endocytosis

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