Reactome | Clathrin-mediated endocytosis

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Clathrin-mediated endocytosis Show undefined attributes

created	[InstanceEdit:9864362] Wright, Adam, 2024-03-07
dbId	9978706
displayName	Clathrin-mediated endocytosis
eventOf	[Pathway:R-MMU-199991] Membrane Trafficking - Mus musculus
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
hasDiagram	true
hasEHLD	false
hasEvent	[Pathway:R-MMU-8856825] Cargo recognition for clathrin-mediated endocytosis - Mus musculus [Reaction:R-MMU-8871196] Initial binding of AP-2 and clathrin to PI(4,5)P2 - Mus musculus [Reaction:R-MMU-8856808] Recruitment of AP-2 complex and clathrin - Mus musculus [Reaction:R-MMU-8868066] PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 - Mus musculus [Reaction:R-MMU-8856813] AAK1 phosphorylates AP-2 mu subunit at T156 - Mus musculus [Reaction:R-MMU-8867756] CLASP proteins and cargo are recruited to the nascent clathrin-coated pit - Mus musculus [Reaction:R-MMU-8868071] Clathrin recruits PIK3C2A - Mus musculus [Reaction:R-MMU-8868072] Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 - Mus musculus [Reaction:R-MMU-8867754] F- and N- BAR domain proteins bind the clathrin-coated pit - Mus musculus [Reaction:R-MMU-8868236] BAR domain proteins recruit dynamin - Mus musculus [Reaction:R-MMU-8868651] Endophilins recruit synaptojanins to the clathrin-coated pit - Mus musculus [Reaction:R-MMU-8868648] SYNJ hydrolyze PI(4,5)P2 to PI(4)P - Mus musculus [Reaction:R-MMU-8868661] Dynamin-mediated GTP hydrolysis promotes vesicle scission - Mus musculus [Reaction:R-MMU-8868659] Clathrin recruits auxilins to the clathrin-coated vesicle - Mus musculus [Reaction:R-MMU-8868660] Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle - Mus musculus [Reaction:R-MMU-8868658] HSPA8-mediated ATP hydrolysis promotes vesicle uncoating - Mus musculus [Reaction:R-MMU-8871194] RAB5 and GAPVD1 bind AP-2 - Mus musculus [BlackBoxEvent:R-MMU-8871193] Dissociation of AAK1 and dephosphorylation of AP-2 mu2 - Mus musculus
inferredFrom	[Pathway:R-HSA-8856828] Clathrin-mediated endocytosis - Homo sapiens
isInDisease	false
isInferred	true
name	Clathrin-mediated endocytosis
releaseDate	2024-03-27
schemaClass	Pathway
species	[Species:48892] Mus musculus
stId	R-MMU-8856828
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-199991] Membrane Trafficking
(hasEncapsulatedEvent)	[Pathway:R-MMU-8856825] Cargo recognition for clathrin-mediated endocytosis
(inferredTo)	[Pathway:R-HSA-8856828] Clathrin-mediated endocytosis

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