Reactome | Cargo recognition for clathrin-mediated endocytosis

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Cargo recognition for clathrin-mediated endocytosis Show undefined attributes

authored	[InstanceEdit:8870660] Rothfels, Karen, 2016-05-10
created	[InstanceEdit:8856824] Rothfels, Karen, 2016-02-11
dbId	8856825
displayName	Cargo recognition for clathrin-mediated endocytosis
edited	[InstanceEdit:8870660] Rothfels, Karen, 2016-05-10
eventOf	[Pathway:R-HSA-8856828] Clathrin-mediated endocytosis - Homo sapiens
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-HSA-8866277] AP-2 directly binds some endocytic cargo - Homo sapiens [Reaction:R-HSA-9681616] AP2 binds chlorpromazine - Homo sapiens [Reaction:R-HSA-8863471] LDLR is bound by DAB2 and ARH - Homo sapiens [Reaction:R-HSA-8863472] DAB2 binds LRP2 - Homo sapiens [Reaction:R-HSA-8866279] Epsin family proteins bind ubiquitinated cargo - Homo sapiens [Reaction:R-HSA-8866275] UBQLNs bind UIM-containing adaptor proteins - Homo sapiens [Reaction:R-HSA-8866268] ADBRK1,2 phosphorylate AVPR2 - Homo sapiens [Reaction:R-HSA-8866269] ARRB bind GPCRs - Homo sapiens [Reaction:R-HSA-8866283] ARBB recruits GPCRs into clathrin-coated pits - Homo sapiens [Reaction:R-HSA-8863718] AGFG1 binds VAMP7 - Homo sapiens [Reaction:R-HSA-8863463] STON2 binds SYT proteins - Homo sapiens [BlackBoxEvent:R-HSA-8863727] STON2 is neddylated - Homo sapiens [Reaction:R-HSA-8863721] NEDD8-STON binds TOR1 hexamer and COP9 complex - Homo sapiens [BlackBoxEvent:R-HSA-8863723] COP9 and TOR1 deneddylate STON2 - Homo sapiens [Reaction:R-HSA-8867613] PICALM binds R-SNAREs - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2020-09-24
literatureReference	[LiteratureReference:8864622] Cargo recognition in clathrin-mediated endocytosis [LiteratureReference:8867565] A single common portal for clathrin-mediated endocytosis of distinct cargo governed by cargo-selective adaptors [LiteratureReference:8866140] Clathrin-mediated endocytosis in AP-2-depleted cells [LiteratureReference:8867585] Roles of AP-2 in clathrin-mediated endocytosis [LiteratureReference:8867727] Tickets to ride: selecting cargo for clathrin-regulated internalization [LiteratureReference:8867021] Analysis of clathrin-mediated endocytosis of epidermal growth factor receptor by RNA interference [LiteratureReference:8862229] FCHo proteins are nucleators of clathrin-mediated endocytosis [LiteratureReference:8870862] Activation of the epidermal growth factor (EGF) receptor induces formation of EGF receptor- and Grb2-containing clathrin-coated pits [LiteratureReference:8870857] AP2 hemicomplexes contribute independently to synaptic vesicle endocytosis
maxDepth	2
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	Cargo recognition for clathrin-mediated endocytosis
orthologousEvent	[Pathway:R-PFA-8856825] Cargo recognition for clathrin-mediated endocytosis - Plasmodium falciparum [Pathway:R-SCE-8856825] Cargo recognition for clathrin-mediated endocytosis - Saccharomyces cerevisiae [Pathway:R-SPO-8856825] Cargo recognition for clathrin-mediated endocytosis - Schizosaccharomyces pombe [Pathway:R-DDI-8856825] Cargo recognition for clathrin-mediated endocytosis - Dictyostelium discoideum [Pathway:R-CEL-8856825] Cargo recognition for clathrin-mediated endocytosis - Caenorhabditis elegans [Pathway:R-DME-8856825] Cargo recognition for clathrin-mediated endocytosis - Drosophila melanogaster [Pathway:R-GGA-8856825] Cargo recognition for clathrin-mediated endocytosis - Gallus gallus [Pathway:R-XTR-8856825] Cargo recognition for clathrin-mediated endocytosis - Xenopus tropicalis [Pathway:R-DRE-8856825] Cargo recognition for clathrin-mediated endocytosis - Danio rerio [Pathway:R-SSC-8856825] Cargo recognition for clathrin-mediated endocytosis - Sus scrofa [Pathway:R-BTA-8856825] Cargo recognition for clathrin-mediated endocytosis - Bos taurus [Pathway:R-CFA-8856825] Cargo recognition for clathrin-mediated endocytosis - Canis familiaris [Pathway:R-RNO-8856825] Cargo recognition for clathrin-mediated endocytosis - Rattus norvegicus [Pathway:R-MMU-8856825] Cargo recognition for clathrin-mediated endocytosis - Mus musculus
releaseDate	2016-06-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8870617] Antonescu, Costin N, 2016-05-10
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-8856825
summation	[Summation:8867609] Recruitment of plasma membrane-localized cargo into clathrin...
updateTrackers	[UpdateTracker:9776835] Update Tracker - [Pathway:8856825] Cargo recognition for clathrin-mediated endocytosis - v74:[addHasEvent, updateContainedRLE]

Referrals

(updatedInstance)	[UpdateTracker:9776835] Update Tracker - [Pathway:8856825] Cargo recognition for clathrin-mediated endocytosis - v74:[addHasEvent, updateContainedRLE]
(hasEvent)	[Pathway:R-HSA-8856828] Clathrin-mediated endocytosis

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