Reactome | Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2

Schema > Reaction > Entries

Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 Show undefined attributes

authored	[InstanceEdit:8870660] Rothfels, Karen, 2016-05-10
catalystActivity	[CatalystActivity:8868073] 1-phosphatidylinositol-4-phosphate 3-kinase activity of PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:8868070] Rothfels, Karen, 2016-04-18
dbId	8868072
displayName	Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2
edited	[InstanceEdit:8870660] Rothfels, Karen, 2016-05-10
eventOf	[Pathway:R-HSA-8856828] Clathrin-mediated endocytosis - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-392417] PI4P [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1675792] The class II phosphoinositide 3-kinase PI3K-C2alpha is concentrated in the trans-Golgi network and present in clathrin-coated vesicles [LiteratureReference:8868029] The class II phosphoinositide 3-kinase C2alpha is activated by clathrin and regulates clathrin-mediated membrane trafficking [LiteratureReference:8867995] Individual phosphoinositide 3-kinase C2alpha domain activities independently regulate clathrin function [LiteratureReference:8868016] Spatiotemporal control of endocytosis by phosphatidylinositol-3,4-bisphosphate [LiteratureReference:8867983] BAR domain scaffolds in dynamin-mediated membrane fission
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2
orthologousEvent	[Reaction:R-CEL-8868072] Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 - Caenorhabditis elegans [Reaction:R-DME-8868072] Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 - Drosophila melanogaster [Reaction:R-GGA-8868072] Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 - Gallus gallus [Reaction:R-XTR-8868072] Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 - Xenopus tropicalis [Reaction:R-SSC-8868072] Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 - Sus scrofa [Reaction:R-BTA-8868072] Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 - Bos taurus [Reaction:R-CFA-8868072] Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 - Canis familiaris [Reaction:R-RNO-8868072] Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 - Rattus norvegicus [Reaction:R-MMU-8868072] Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 - Mus musculus
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-202247] PI(3,4)P2 [plasma membrane]
precedingEvent	[Reaction:R-HSA-8868071] Clathrin recruits PIK3C2A - Homo sapiens
releaseDate	2016-06-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8870617] Antonescu, Costin N, 2016-05-10
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8868072
summation	[Summation:8868061] Clathrin-associated PIK3C2A catalyzes the conversion of PI(4...

Referrals

(hasEvent)

[Pathway:R-HSA-8856828] Clathrin-mediated endocytosis