Reactome | CLASP proteins and cargo are recruited to the nascent clathrin-coated pit

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CLASP proteins and cargo are recruited to the nascent clathrin-coated pit Show undefined attributes

authored	[InstanceEdit:8870660] Rothfels, Karen, 2016-05-10
category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:8867755] Rothfels, Karen, 2016-04-16
dbId	8867756
displayName	CLASP proteins and cargo are recruited to the nascent clathrin-coated pit
edited	[InstanceEdit:8870660] Rothfels, Karen, 2016-05-10
eventOf	[Pathway:R-HSA-8856828] Clathrin-mediated endocytosis - Homo sapiens
followingEvent	[Reaction:R-HSA-8868071] Clathrin recruits PIK3C2A - Homo sapiens
input	[DefinedSet:R-HSA-8867603] CLASP proteins:cargo [plasma membrane] [Complex:R-HSA-8856806] PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8871098] Local clustering of transferrin receptors promotes clathrin-coated pit initiation [LiteratureReference:8856473] Molecular mechanism and physiological functions of clathrin-mediated endocytosis [LiteratureReference:8863700] Role of the AP2 beta-appendage hub in recruiting partners for clathrin-coated vesicle assembly [LiteratureReference:8864680] Molecular switches involving the AP-2 beta2 appendage regulate endocytic cargo selection and clathrin coat assembly [LiteratureReference:8867727] Tickets to ride: selecting cargo for clathrin-regulated internalization [LiteratureReference:8864622] Cargo recognition in clathrin-mediated endocytosis [LiteratureReference:8867692] Molecular structure, function, and dynamics of clathrin-mediated membrane traffic [LiteratureReference:8867678] Cargo and dynamin regulate clathrin-coated pit maturation [LiteratureReference:8867689] Endocytic accessory proteins are functionally distinguished by their differential effects on the maturation of clathrin-coated pits [LiteratureReference:8867686] Divergent modes for cargo-mediated control of clathrin-coated pit dynamics [LiteratureReference:8870865] Cargo- and adaptor-specific mechanisms regulate clathrin-mediated endocytosis [LiteratureReference:8871087] Cargo regulates clathrin-coated pit dynamics
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	CLASP proteins and cargo are recruited to the nascent clathrin-coated pit
orthologousEvent	[Reaction:R-CEL-8867756] CLASP proteins and cargo are recruited to the nascent clathrin-coated pit - Caenorhabditis elegans [Reaction:R-DME-8867756] CLASP proteins and cargo are recruited to the nascent clathrin-coated pit - Drosophila melanogaster [Reaction:R-GGA-8867756] CLASP proteins and cargo are recruited to the nascent clathrin-coated pit - Gallus gallus [Reaction:R-XTR-8867756] CLASP proteins and cargo are recruited to the nascent clathrin-coated pit - Xenopus tropicalis [Reaction:R-SSC-8867756] CLASP proteins and cargo are recruited to the nascent clathrin-coated pit - Sus scrofa [Reaction:R-BTA-8867756] CLASP proteins and cargo are recruited to the nascent clathrin-coated pit - Bos taurus [Reaction:R-CFA-8867756] CLASP proteins and cargo are recruited to the nascent clathrin-coated pit - Canis familiaris [Reaction:R-RNO-8867756] CLASP proteins and cargo are recruited to the nascent clathrin-coated pit - Rattus norvegicus [Reaction:R-MMU-8867756] CLASP proteins and cargo are recruited to the nascent clathrin-coated pit - Mus musculus
output	[Complex:R-HSA-8867753] PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane]
precedingEvent	[Reaction:R-HSA-8863718] AGFG1 binds VAMP7 - Homo sapiens [Reaction:R-HSA-8866277] AP-2 directly binds some endocytic cargo - Homo sapiens [Reaction:R-HSA-8866283] ARBB recruits GPCRs into clathrin-coated pits - Homo sapiens [Reaction:R-HSA-8866269] ARRB bind GPCRs - Homo sapiens [Reaction:R-HSA-8863472] DAB2 binds LRP2 - Homo sapiens [Reaction:R-HSA-8866279] Epsin family proteins bind ubiquitinated cargo - Homo sapiens [Reaction:R-HSA-8863471] LDLR is bound by DAB2 and ARH - Homo sapiens [Reaction:R-HSA-8867613] PICALM binds R-SNAREs - Homo sapiens [Reaction:R-HSA-8863463] STON2 binds SYT proteins - Homo sapiens [Reaction:R-HSA-8856813] AAK1 phosphorylates AP-2 mu subunit at T156 - Homo sapiens
releaseDate	2016-06-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8870617] Antonescu, Costin N, 2016-05-10
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8867756
summation	[Summation:8867615] CLASP proteins are recruited to nascent clathrin-coated pits...

Referrals

(hasEvent)	[Pathway:R-HSA-8856828] Clathrin-mediated endocytosis
(precedingEvent)	[Reaction:R-HSA-8868071] Clathrin recruits PIK3C2A

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