Reactome | HSPA8-mediated ATP hydrolysis promotes vesicle uncoating

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HSPA8-mediated ATP hydrolysis promotes vesicle uncoating Show undefined attributes

authored	[InstanceEdit:8870660] Rothfels, Karen, 2016-05-10
catalystActivity	[CatalystActivity:8868656] ATP hydrolysis activity of PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane]
category	transition
compartment	[Compartment:24339] clathrin-coated endocytic vesicle membrane
created	[InstanceEdit:8868662] Rothfels, Karen, 2016-04-22
dbId	8868658
displayName	HSPA8-mediated ATP hydrolysis promotes vesicle uncoating
edited	[InstanceEdit:8870660] Rothfels, Karen, 2016-05-10
eventOf	[Pathway:R-HSA-8856828] Clathrin-mediated endocytosis - Homo sapiens
followingEvent	[Reaction:R-HSA-8871194] RAB5 and GAPVD1 bind AP-2 - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [Complex:R-HSA-8868627] PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8868543] The role of molecular chaperones in clathrin mediated vesicular trafficking [LiteratureReference:8868697] Auxilin-induced interaction of the molecular chaperone Hsc70 with clathrin baskets [LiteratureReference:8868424] A motif in the clathrin heavy chain required for the Hsc70/auxilin uncoating reaction [LiteratureReference:8868515] Structure of clathrin coat with bound Hsc70 and auxilin: mechanism of Hsc70-facilitated disassembly [LiteratureReference:8868442] An enzyme that removes clathrin coats: purification of an uncoating ATPase
modified	[InstanceEdit:10740525] Wright, Adam, 2024-03-08
name	HSPA8-mediated ATP hydrolysis promotes vesicle uncoating
orthologousEvent	[Reaction:R-CEL-8868658] HSPA8-mediated ATP hydrolysis promotes vesicle uncoating - Caenorhabditis elegans [Reaction:R-DME-8868658] HSPA8-mediated ATP hydrolysis promotes vesicle uncoating - Drosophila melanogaster [Reaction:R-GGA-8868658] HSPA8-mediated ATP hydrolysis promotes vesicle uncoating - Gallus gallus [Reaction:R-SSC-8868658] HSPA8-mediated ATP hydrolysis promotes vesicle uncoating - Sus scrofa [Reaction:R-BTA-8868658] HSPA8-mediated ATP hydrolysis promotes vesicle uncoating - Bos taurus [Reaction:R-CFA-8868658] HSPA8-mediated ATP hydrolysis promotes vesicle uncoating - Canis familiaris [Reaction:R-RNO-8868658] HSPA8-mediated ATP hydrolysis promotes vesicle uncoating - Rattus norvegicus [Reaction:R-MMU-8868658] HSPA8-mediated ATP hydrolysis promotes vesicle uncoating - Mus musculus
output	[Complex:R-HSA-8868617] clathrin:HSPA8:ADP [cytosol] [SimpleEntity:R-ALL-29372] Pi [cytosol] [Complex:R-HSA-8868620] PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane]
precedingEvent	[Reaction:R-HSA-8868660] Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle - Homo sapiens
releaseDate	2016-06-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8870617] Antonescu, Costin N, 2016-05-10
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8868658
summation	[Summation:8868707] HSPA8 hydrolyzes ATP to promote dissociation of the clathrin...

Referrals

(precedingEvent)	[Reaction:R-HSA-8871194] RAB5 and GAPVD1 bind AP-2
(hasEvent)	[Pathway:R-HSA-8856828] Clathrin-mediated endocytosis

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