Reactome | AAK1 phosphorylates AP-2 mu subunit at T156

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AAK1 phosphorylates AP-2 mu subunit at T156 Show undefined attributes

authored	[InstanceEdit:8870660] Rothfels, Karen, 2016-05-10
catalystActivity	[CatalystActivity:8856814] protein serine/threonine kinase activity of PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:8856812] Rothfels, Karen, 2016-02-11
dbId	8856813
displayName	AAK1 phosphorylates AP-2 mu subunit at T156
edited	[InstanceEdit:8870660] Rothfels, Karen, 2016-05-10
eventOf	[Pathway:R-HSA-8856828] Clathrin-mediated endocytosis - Homo sapiens
followingEvent	[Reaction:R-HSA-8867756] CLASP proteins and cargo are recruited to the nascent clathrin-coated pit - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-8868048] PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8856490] Phosphorylation of threonine 156 of the mu2 subunit of the AP2 complex is essential for endocytosis in vitro and in vivo [LiteratureReference:8856467] Identification of an adaptor-associated kinase, AAK1, as a regulator of clathrin-mediated endocytosis [LiteratureReference:8856451] AAK1-mediated micro2 phosphorylation is stimulated by assembled clathrin [LiteratureReference:8856488] Phosphorylation of the AP2 mu subunit by AAK1 mediates high affinity binding to membrane protein sorting signals [LiteratureReference:8856800] A novel AAK1 splice variant functions at multiple steps of the endocytic pathway
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	AAK1 phosphorylates AP-2 mu subunit at T156
orthologousEvent	[Reaction:R-DDI-8856813] AAK1 phosphorylates AP-2 mu subunit at T156 - Dictyostelium discoideum [Reaction:R-CEL-8856813] AAK1 phosphorylates AP-2 mu subunit at T156 - Caenorhabditis elegans [Reaction:R-DME-8856813] AAK1 phosphorylates AP-2 mu subunit at T156 - Drosophila melanogaster [Reaction:R-GGA-8856813] AAK1 phosphorylates AP-2 mu subunit at T156 - Gallus gallus [Reaction:R-XTR-8856813] AAK1 phosphorylates AP-2 mu subunit at T156 - Xenopus tropicalis [Reaction:R-SSC-8856813] AAK1 phosphorylates AP-2 mu subunit at T156 - Sus scrofa [Reaction:R-BTA-8856813] AAK1 phosphorylates AP-2 mu subunit at T156 - Bos taurus [Reaction:R-CFA-8856813] AAK1 phosphorylates AP-2 mu subunit at T156 - Canis familiaris [Reaction:R-RNO-8856813] AAK1 phosphorylates AP-2 mu subunit at T156 - Rattus norvegicus [Reaction:R-MMU-8856813] AAK1 phosphorylates AP-2 mu subunit at T156 - Mus musculus
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-8856806] PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane]
precedingEvent	[Reaction:R-HSA-8856808] Recruitment of AP-2 complex and clathrin - Homo sapiens
releaseDate	2016-06-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8870617] Antonescu, Costin N, 2016-05-10
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8856813
summation	[Summation:8856802] AAK1 is a serine-threonine kinase that phosphorylates T156 o...

Referrals

(hasEvent)	[Pathway:R-HSA-8856828] Clathrin-mediated endocytosis
(precedingEvent)	[Reaction:R-HSA-8867756] CLASP proteins and cargo are recruited to the nascent clathrin-coated pit

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