Reactome | RAB5 and GAPVD1 bind AP-2

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RAB5 and GAPVD1 bind AP-2 Show undefined attributes

authored	[InstanceEdit:8871191] Rothfels, Karen, 2016-05-13
category	binding
compartment	[Compartment:24339] clathrin-coated endocytic vesicle membrane
created	[InstanceEdit:8871192] Rothfels, Karen, 2016-05-13
dbId	8871194
displayName	RAB5 and GAPVD1 bind AP-2
edited	[InstanceEdit:8871191] Rothfels, Karen, 2016-05-13
eventOf	[Pathway:R-HSA-8856828] Clathrin-mediated endocytosis - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-8871193] Dissociation of AAK1 and dephosphorylation of AP-2 mu2 - Homo sapiens
input	[Complex:R-HSA-8871139] GGC-RAB5:GDP:GAPVD1 [clathrin-coated endocytic vesicle membrane] [Complex:R-HSA-8868620] PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8871102] Localization of low molecular weight GTP binding proteins to exocytic and endocytic compartments [LiteratureReference:8871045] A novel role for Rab5-GDI in ligand sequestration into clathrin-coated pits [LiteratureReference:8868162] A high precision survey of the molecular dynamics of mammalian clathrin-mediated endocytosis [LiteratureReference:8855098] Rab GTPases as coordinators of vesicle traffic [LiteratureReference:8871106] Rab proteins and the compartmentalization of the endosomal system [LiteratureReference:8871080] Caenorhabditis elegans RME-6 is a novel regulator of RAB-5 at the clathrin-coated pit [LiteratureReference:8871093] Coordinated regulation of AP2 uncoating from clathrin-coated vesicles by rab5 and hRME-6 [LiteratureReference:1011609] Phosphatidylinositol-3-OH kinases are Rab5 effectors [LiteratureReference:5671657] An enzymatic cascade of Rab5 effectors regulates phosphoinositide turnover in the endocytic pathway [LiteratureReference:8871109] Rab5-activating protein 6, a novel endosomal protein with a role in endocytosis
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	RAB5 and GAPVD1 bind AP-2
orthologousEvent	[Reaction:R-CEL-8871194] RAB5 and GAPVD1 bind AP-2 - Caenorhabditis elegans [Reaction:R-DME-8871194] RAB5 and GAPVD1 bind AP-2 - Drosophila melanogaster [Reaction:R-GGA-8871194] RAB5 and GAPVD1 bind AP-2 - Gallus gallus [Reaction:R-SSC-8871194] RAB5 and GAPVD1 bind AP-2 - Sus scrofa [Reaction:R-BTA-8871194] RAB5 and GAPVD1 bind AP-2 - Bos taurus [Reaction:R-CFA-8871194] RAB5 and GAPVD1 bind AP-2 - Canis familiaris [Reaction:R-RNO-8871194] RAB5 and GAPVD1 bind AP-2 - Rattus norvegicus [Reaction:R-MMU-8871194] RAB5 and GAPVD1 bind AP-2 - Mus musculus
output	[Complex:R-HSA-8871149] PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane]
precedingEvent	[Reaction:R-HSA-8868658] HSPA8-mediated ATP hydrolysis promotes vesicle uncoating - Homo sapiens
releaseDate	2016-06-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8870617] Antonescu, Costin N, 2016-05-10
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8871194
summation	[Summation:8871183] RAB5 is a small GTPase that is implicated in clathrin-mediat...

Referrals

(hasEvent)	[Pathway:R-HSA-8856828] Clathrin-mediated endocytosis
(precedingEvent)	[BlackBoxEvent:R-HSA-8871193] Dissociation of AAK1 and dephosphorylation of AP-2 mu2

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