Reactome | Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq

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Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq Show undefined attributes

authored	[InstanceEdit:745612] Jupe, S, 2010-05-18
category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:749449] Jupe, S, 2010-05-18
dbId	749448
displayName	Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq
edited	[InstanceEdit:813668] Jupe, S, 2010-05-26
eventOf	[Pathway:R-HSA-416476] G alpha (q) signalling events - Homo sapiens
followingEvent	[Reaction:R-HSA-379048] Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 - Homo sapiens
input	[Complex:R-HSA-114557] Heterotrimeric G-protein Gq/11 (inactive) [plasma membrane] [DefinedSet:R-HSA-380110] Ligand:GPCR complexes that activate Gq/11 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:383358] Stable association between G alpha(q) and phospholipase C beta 1 in living cells
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq
orthologousEvent	[Reaction:R-MMU-749448] Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq - Mus musculus [Reaction:R-CFA-749448] Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq - Canis familiaris [Reaction:R-BTA-749448] Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq - Bos taurus [Reaction:R-GGA-749448] Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq - Gallus gallus [Reaction:R-CEL-749448] Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq - Caenorhabditis elegans
output	[Complex:R-HSA-749451] Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane]
precedingEvent	[Reaction:R-HSA-374173] AGT(25-32) binds to AGTR1 - Homo sapiens [Reaction:R-HSA-9615348] AGT(25-32) binds to AGTR2 - Homo sapiens [Reaction:R-HSA-375384] Bombesin-like receptors bind bombesin homologues - Homo sapiens [Reaction:R-HSA-374331] Bradykinin receptors B1 and B2 bind to bradykinin - Homo sapiens [Reaction:R-HSA-390649] CHRM1,3,5 bind acetylcholine - Homo sapiens [Reaction:R-HSA-390930] 5-HT2 receptor can bind serotonin - Homo sapiens [Reaction:R-HSA-390641] ADRA1A,B,D bind ADR,NAd - Homo sapiens [Reaction:R-HSA-390912] HRH1 binds hist - Homo sapiens [Reaction:R-HSA-391372] GNRHR binds GNRH1,2 - Homo sapiens [Reaction:R-HSA-388468] AVP(20-28) binds AVPR1A,B - Homo sapiens [Reaction:R-HSA-417908] P2RY1 binds ADP - Homo sapiens [Reaction:R-HSA-417927] P2Y2 receptor binds ATP and UTP - Homo sapiens [Reaction:R-HSA-417890] P2Y5 receptor can bind to LPA - Homo sapiens [Reaction:R-HSA-417896] P2Y6 receptor can bind to UDP - Homo sapiens [Reaction:R-HSA-417842] P2Y10 receptor can bind to LPA - Homo sapiens [Reaction:R-HSA-417820] P2Y9 receptor can bind to LPA - Homo sapiens [Reaction:R-HSA-163625] Glucagon binds to Glucagon receptor - Homo sapiens [Reaction:R-HSA-419861] Melanospin is stimulated by light - Homo sapiens [Reaction:R-HSA-420724] CASR binds Ca2+ - Homo sapiens [Reaction:R-HSA-444208] MLNR (GPR38) is a receptor for motilin - Homo sapiens [Reaction:R-HSA-444498] Thyrotropin-releasing hormone receptor binds thyrotropin - Homo sapiens [Reaction:R-HSA-444620] Neuropeptide S receptor binds neuropeptide S - Homo sapiens [Reaction:R-HSA-444691] Prokineticin receptors bind prokineticin - Homo sapiens [Reaction:R-HSA-444202] Receptor FFAR1 binds free fatty acids - Homo sapiens [Reaction:R-HSA-444171] Receptor FFAR2 binds carboxylates - Homo sapiens [Reaction:R-HSA-444047] Receptor FFAR3 binds carboxylates - Homo sapiens [Reaction:R-HSA-445113] Urotensin-2 receptor binds urotensin-2 and 2B - Homo sapiens [Reaction:R-HSA-444731] GPR4, GPR65, GPR132 and OGR1 are pH sensing receptors - Homo sapiens [Reaction:R-HSA-947647] GHSR is a receptor for ghrelin - Homo sapiens [Reaction:R-HSA-981832] NMUR2 binds neuromedin-S - Homo sapiens [Reaction:R-HSA-964800] Neuromedin-U receptors bind neuromedins U, S - Homo sapiens [Reaction:R-HSA-870269] Gastrin binds to CCK-B receptor - Homo sapiens [Reaction:R-HSA-373075] Metabotropic glutamate receptors bind glutamate - Homo sapiens [Reaction:R-HSA-444191] GPR120 is a receptor for unsaturated long-chain free fatty acids - Homo sapiens [Reaction:R-HSA-444572] Zinc is an agonist of GPR39 - Homo sapiens
releaseDate	2010-06-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:782850] D'Eustachio, P, 2010-05-21
revised	[InstanceEdit:9012014] Varusai, Thawfeek, 2017-07-10
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-749448
summation	[Summation:751020] Numerous functionally unrelated GPCRs couple with the Gq G-p...

Referrals

(precedingEvent)	[Reaction:R-HSA-379048] Liganded Gq/11-activating GPCRs act as GEFs for Gq/11
(hasEvent)	[Pathway:R-HSA-416476] G alpha (q) signalling events

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