Reactome | Liganded Gq/11-activating GPCRs act as GEFs for Gq/11

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Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 Show undefined attributes

authored	[InstanceEdit:380069] Jassal, Bijay, 2008-11-07
catalystActivity	[CatalystActivity:380089] guanyl-nucleotide exchange factor activity of LTC4:CyslTR1,2 [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:379045] Jassal, Bijay, 2008-10-10
dbId	379048
displayName	Liganded Gq/11-activating GPCRs act as GEFs for Gq/11
edited	[InstanceEdit:813668] Jupe, S, 2010-05-26
eventOf	[Pathway:R-HSA-416476] G alpha (q) signalling events - Homo sapiens
followingEvent	[Reaction:R-HSA-749452] The Ligand:GPCR:Gq complex dissociates - Homo sapiens
input	[SimpleEntity:R-ALL-29438] GTP [cytosol] [Complex:R-HSA-749451] Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:750995] The influence of bound GDP on the kinetics of guanine nucleotide binding to G proteins [LiteratureReference:383358] Stable association between G alpha(q) and phospholipase C beta 1 in living cells [LiteratureReference:383349] Genomic organization of the human galpha14 and Galphaq genes and mutation analysis in chorea-acanthocytosis (CHAC) [LiteratureReference:383352] G alpha 16, a G protein alpha subunit specifically expressed in hematopoietic cells [LiteratureReference:383347] Human G(alpha q): cDNA and tissue distribution
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Liganded Gq/11-activating GPCRs act as GEFs for Gq/11
orthologousEvent	[Reaction:R-CEL-379048] Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 - Caenorhabditis elegans [Reaction:R-GGA-379048] Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 - Gallus gallus [Reaction:R-DRE-379048] Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 - Danio rerio [Reaction:R-SSC-379048] Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 - Sus scrofa [Reaction:R-BTA-379048] Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 - Bos taurus [Reaction:R-CFA-379048] Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 - Canis familiaris [Reaction:R-RNO-379048] Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 - Rattus norvegicus [Reaction:R-MMU-379048] Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 - Mus musculus
output	[SimpleEntity:R-ALL-29420] GDP [cytosol] [Complex:R-HSA-749447] Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane]
precedingEvent	[Reaction:R-HSA-749448] Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq - Homo sapiens
releaseDate	2008-12-17
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:387043] D'Eustachio, P, 2008-11-29 18:33:05
revised	[InstanceEdit:9012014] Varusai, Thawfeek, 2017-07-10
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-379048
summation	[Summation:380079] G alpha q protein (or Gq/11) consists of four family members...
updateTrackers	[UpdateTracker:9790686] Update Tracker - [Reaction:379048] Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 - v33:[addLiteratureReference, add_removeInput, add_removeOutput] [UpdateTracker:9791628] Update Tracker - [Reaction:379048] Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 - v28:[add_removeOutput]

Referrals

(updatedInstance)	[UpdateTracker:9790686] Update Tracker - [Reaction:379048] Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 - v33:[addLiteratureReference, add_removeInput, add_removeOutput] [UpdateTracker:9791628] Update Tracker - [Reaction:379048] Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 - v28:[add_removeOutput]
(hasEvent)	[Pathway:R-HSA-416476] G alpha (q) signalling events
(precedingEvent)	[Reaction:R-HSA-749452] The Ligand:GPCR:Gq complex dissociates

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