Reactome | GPR4, GPR65, GPR132 and OGR1 are pH sensing receptors

Schema > Reaction > Entries

GPR4, GPR65, GPR132 and OGR1 are pH sensing receptors Show undefined attributes

authored	[InstanceEdit:444580] Jupe, S, 2009-10-23
category	binding
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:444617] Jupe, S, 2009-10-26
dbId	444731
displayName	GPR4, GPR65, GPR132 and OGR1 are pH sensing receptors
edited	[InstanceEdit:532507] Jupe, S, 2010-03-01
eventOf	[Pathway:R-HSA-373076] Class A/1 (Rhodopsin-like receptors) - Homo sapiens
followingEvent	[Reaction:R-HSA-749448] Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq - Homo sapiens
input	[SimpleEntity:R-ALL-351626] H+ [extracellular region] [DefinedSet:R-HSA-444736] pH sensing receptors [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:444741] Proton-sensing G-protein-coupled receptors [LiteratureReference:444608] Previously postulated "ligand-independent" signaling of GPR4 is mediated through proton-sensing mechanisms [LiteratureReference:444721] TDAG8 is a proton-sensing and psychosine-sensitive G-protein-coupled receptor [LiteratureReference:444674] G2A is a proton-sensing G-protein-coupled receptor antagonized by lysophosphatidylcholine
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	GPR4, GPR65, GPR132 and OGR1 are pH sensing receptors
orthologousEvent	[Reaction:R-CEL-444731] GPR4, GPR65, GPR132 and OGR1 are pH sensing receptors - Caenorhabditis elegans [Reaction:R-GGA-444731] GPR4, GPR65, GPR132 and OGR1 are pH sensing receptors - Gallus gallus [Reaction:R-XTR-444731] GPR4, GPR65, GPR132 and OGR1 are pH sensing receptors - Xenopus tropicalis [Reaction:R-DRE-444731] GPR4, GPR65, GPR132 and OGR1 are pH sensing receptors - Danio rerio [Reaction:R-SSC-444731] GPR4, GPR65, GPR132 and OGR1 are pH sensing receptors - Sus scrofa [Reaction:R-BTA-444731] GPR4, GPR65, GPR132 and OGR1 are pH sensing receptors - Bos taurus [Reaction:R-CFA-444731] GPR4, GPR65, GPR132 and OGR1 are pH sensing receptors - Canis familiaris [Reaction:R-RNO-444731] GPR4, GPR65, GPR132 and OGR1 are pH sensing receptors - Rattus norvegicus [Reaction:R-MMU-444731] GPR4, GPR65, GPR132 and OGR1 are pH sensing receptors - Mus musculus
output	[Complex:R-HSA-444739] pH sensing receptors:H+ [plasma membrane]
releaseDate	2010-03-16
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:450112] D'Eustachio, P, 2009-12-11
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-444731
summation	[Summation:444678] The subfamily of G protein-coupled receptors comprising GPR4...

Referrals

(hasEvent)	[Pathway:R-HSA-373076] Class A/1 (Rhodopsin-like receptors)
(precedingEvent)	[Reaction:R-HSA-749448] Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq