Reactome | Glucagon binds to Glucagon receptor

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Glucagon binds to Glucagon receptor Show undefined attributes

authored	[InstanceEdit:163620] Gopinathrao, G, 2005-05-03 20:30:53
catalystActivity	[CatalystActivity:9857011] glucagon receptor activity of GCGR [plasma membrane]
category	transition
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:163620] Gopinathrao, G, 2005-05-03 20:30:53
dbId	163625
displayName	Glucagon binds to Glucagon receptor
edited	[InstanceEdit:420077] Jassal, Bijay, 2009-05-11
eventOf	[Pathway:R-HSA-163359] Glucagon signaling in metabolic regulation - Homo sapiens [Pathway:R-HSA-420092] Glucagon-type ligand receptors - Homo sapiens
followingEvent	[Reaction:R-HSA-825631] Glucagon:GCGR mediates GTP-GDP exchange - Homo sapiens [Reaction:R-HSA-749448] Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq - Homo sapiens [Reaction:R-HSA-9660828] ADORA2B:Ade-Rib binds heterometric G-protein Gs - Homo sapiens [Reaction:R-HSA-744887] Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-163626] GCG(53-81) [extracellular region] [EntityWithAccessionedSequence:R-HSA-9820623] GCGR [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:164049] Identification of the lesion in the stimulatory GTP-binding protein of the uncoupled S49 lymphoma [LiteratureReference:164180] Hepatic glucagon receptor binding and glucose-lowering in vivo by peptidyl and non-peptidyl glucagon receptor antagonists [LiteratureReference:420120] The amino acid sequence of human glucagon [LiteratureReference:420150] The human glucagon receptor encoding gene: structure, cDNA sequence and chromosomal localization
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	Glucagon binds to Glucagon receptor
orthologousEvent	[Reaction:R-GGA-163625] Glucagon binds to Glucagon receptor - Gallus gallus [Reaction:R-XTR-163625] Glucagon binds to Glucagon receptor - Xenopus tropicalis [Reaction:R-DRE-163625] Glucagon binds to Glucagon receptor - Danio rerio [Reaction:R-SSC-163625] Glucagon binds to Glucagon receptor - Sus scrofa [Reaction:R-BTA-163625] Glucagon binds to Glucagon receptor - Bos taurus [Reaction:R-CFA-163625] Glucagon binds to Glucagon receptor - Canis familiaris [Reaction:R-RNO-163625] Glucagon binds to Glucagon receptor - Rattus norvegicus [Reaction:R-MMU-163625] Glucagon binds to Glucagon receptor - Mus musculus
output	[Complex:R-HSA-163627] GCGR:GCG(53-81) [plasma membrane]
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2009-06-24
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:422381] D'Eustachio, P, 2009-05-29 07:44:22 [InstanceEdit:9860019] D'Eustachio, Peter, 2024-01-29 [InstanceEdit:9953061] Hill, David P, 2025-05-28
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-163625
summation	[Summation:420110] Glucagon (Thomsen J et al, 1972) is an important peptide hor...
updateTrackers	[UpdateTracker:9790599] Update Tracker - [Reaction:163625] Glucagon binds to Glucagon receptor - v33:[modifyText] [UpdateTracker:9846854] Update Tracker - [Reaction:163625] Glucagon binds to Glucagon receptor - v83:[add_removeInput, modifyText] [UpdateTracker:9791497] Update Tracker - [Reaction:163625] Glucagon binds to Glucagon receptor - v29:[addLiteratureReference, add_removeSummation] [UpdateTracker:9864310] Update Tracker - [Reaction:163625] Glucagon binds to Glucagon receptor - v88:[addCatalystActivity]

Referrals

(updatedInstance)	[UpdateTracker:9790599] Update Tracker - [Reaction:163625] Glucagon binds to Glucagon receptor - v33:[modifyText] [UpdateTracker:9846854] Update Tracker - [Reaction:163625] Glucagon binds to Glucagon receptor - v83:[add_removeInput, modifyText] [UpdateTracker:9791497] Update Tracker - [Reaction:163625] Glucagon binds to Glucagon receptor - v29:[addLiteratureReference, add_removeSummation] [UpdateTracker:9864310] Update Tracker - [Reaction:163625] Glucagon binds to Glucagon receptor - v88:[addCatalystActivity]
(hasEvent)	[Pathway:R-HSA-420092] Glucagon-type ligand receptors [Pathway:R-HSA-163359] Glucagon signaling in metabolic regulation
(precedingEvent)	[Reaction:R-HSA-825631] Glucagon:GCGR mediates GTP-GDP exchange [Reaction:R-HSA-9660828] ADORA2B:Ade-Rib binds heterometric G-protein Gs [Reaction:R-HSA-744887] Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs [Reaction:R-HSA-749448] Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq

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