Reactome | Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq

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Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq Show undefined attributes

category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10020755
displayName	Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq
eventOf	[Pathway:R-MMU-416476] G alpha (q) signalling events - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-379048] Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 - Mus musculus
inferredFrom	[Reaction:R-HSA-749448] Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq - Homo sapiens
input	[Complex:R-MMU-114557] Heterotrimeric G-protein Gq/11 (inactive) [plasma membrane] [DefinedSet:R-MMU-380110] Ligand:GPCR complexes that activate Gq/11 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq
output	[Complex:R-MMU-749451] Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane]
precedingEvent	[Reaction:R-MMU-374173] AGT(25-32) binds to AGTR1 - Mus musculus [Reaction:R-MMU-9615348] AGT(25-32) binds to AGTR2 - Mus musculus [Reaction:R-MMU-375384] Bombesin-like receptors bind bombesin homologues - Mus musculus [Reaction:R-MMU-374331] Bradykinin receptors B1 and B2 bind to bradykinin - Mus musculus [Reaction:R-MMU-390649] CHRM1,3,5 bind acetylcholine - Mus musculus [Reaction:R-MMU-390930] 5-HT2 receptor can bind serotonin - Mus musculus [Reaction:R-MMU-390641] ADRA1A,B,D bind ADR,NAd - Mus musculus [Reaction:R-MMU-390912] HRH1 binds hist - Mus musculus [Reaction:R-MMU-391372] GNRHR binds GNRH1,2 - Mus musculus [Reaction:R-MMU-388468] AVP(20-28) binds AVPR1A,B - Mus musculus [Reaction:R-MMU-417908] P2RY1 binds ADP - Mus musculus [Reaction:R-MMU-417927] P2Y2 receptor binds ATP and UTP - Mus musculus [Reaction:R-MMU-417890] P2Y5 receptor can bind to LPA - Mus musculus [Reaction:R-MMU-417896] P2Y6 receptor can bind to UDP - Mus musculus [Reaction:R-MMU-417842] P2Y10 receptor can bind to LPA - Mus musculus [Reaction:R-MMU-417820] P2Y9 receptor can bind to LPA - Mus musculus [Reaction:R-MMU-163625] Glucagon binds to Glucagon receptor - Mus musculus [Reaction:R-MMU-419861] Melanospin is stimulated by light - Mus musculus [Reaction:R-MMU-420724] CASR binds Ca2+ - Mus musculus [Reaction:R-MMU-444498] Thyrotropin-releasing hormone receptor binds thyrotropin - Mus musculus [Reaction:R-MMU-444620] Neuropeptide S receptor binds neuropeptide S - Mus musculus [Reaction:R-MMU-444691] Prokineticin receptors bind prokineticin - Mus musculus [Reaction:R-MMU-444202] Receptor FFAR1 binds free fatty acids - Mus musculus [Reaction:R-MMU-444171] Receptor FFAR2 binds carboxylates - Mus musculus [Reaction:R-MMU-444047] Receptor FFAR3 binds carboxylates - Mus musculus [Reaction:R-MMU-445113] Urotensin-2 receptor binds urotensin-2 and 2B - Mus musculus [Reaction:R-MMU-444731] GPR4, GPR65, GPR132 and OGR1 are pH sensing receptors - Mus musculus [Reaction:R-MMU-981832] NMUR2 binds neuromedin-S - Mus musculus [Reaction:R-MMU-964800] Neuromedin-U receptors bind neuromedins U, S - Mus musculus [Reaction:R-MMU-870269] Gastrin binds to CCK-B receptor - Mus musculus [Reaction:R-MMU-373075] Metabotropic glutamate receptors bind glutamate - Mus musculus [Reaction:R-MMU-444572] Zinc is an agonist of GPR39 - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-749448
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-416476] G alpha (q) signalling events
(precedingEvent)	[Reaction:R-MMU-379048] Liganded Gq/11-activating GPCRs act as GEFs for Gq/11
(inferredTo)	[Reaction:R-HSA-749448] Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq

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