Reactome | G alpha (q) signalling events

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G alpha (q) signalling events Show undefined attributes

authored	[InstanceEdit:392872] Jupe, S, 2009-03-09 15:04:20
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:416475] Jupe, S, 2009-03-27 12:35:50
crossReference	[DatabaseIdentifier:12819463] BioModels Database:BIOMD0000000088
dbId	416476
displayName	G alpha (q) signalling events
edited	[InstanceEdit:392872] Jupe, S, 2009-03-09 15:04:20
eventOf	[Pathway:R-HSA-388396] GPCR downstream signalling - Homo sapiens
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-HSA-749448] Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq - Homo sapiens [Reaction:R-HSA-379048] Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 - Homo sapiens [Reaction:R-HSA-749452] The Ligand:GPCR:Gq complex dissociates - Homo sapiens [Reaction:R-HSA-416516] GRK2 sequesters activated Gq - Homo sapiens [Reaction:R-HSA-416510] GRK5 sequesters activated Gq - Homo sapiens [Reaction:R-HSA-400586] G alpha (q) binds to Trio family RhoGEFs - Homo sapiens [Reaction:R-HSA-398188] PLC beta is activated by G alpha (q) - Homo sapiens [Reaction:R-HSA-416358] G alpha (q) inhibits PI3K alpha - Homo sapiens [Reaction:R-HSA-418582] G alpha (q) auto-inactivates by hydrolysing GTP to GDP - Homo sapiens [Reaction:R-HSA-750993] Inactive G alpha (q) reassociates with G beta:gamma - Homo sapiens [Pathway:R-HSA-114508] Effects of PIP2 hydrolysis - Homo sapiens [Reaction:R-HSA-8964280] Active Gq binds BTK - Homo sapiens [Reaction:R-HSA-8964284] BTK in active Gq-BTK complex is activated - Homo sapiens [Reaction:R-HSA-8964340] Gq-BTK complex dissociates to Active BTK and Gq - Homo sapiens [Reaction:R-HSA-8982017] Active G alpha (q) binds RGS proteins - Homo sapiens [Reaction:R-HSA-8982025] G alpha (q) in G (q):RGS complex is inactivated - Homo sapiens [Reaction:R-HSA-8982026] G alpha (q):RGS dissociates to inactive G alpha (q) - Homo sapiens [Reaction:R-HSA-114688] PLC-beta hydrolyses PIP2 to DAG and IP3 - Homo sapiens [Pathway:R-HSA-881907] Gastrin-CREB signalling pathway via PKC and MAPK - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2023-03-29
literatureReference	[LiteratureReference:428732] Functions and regulatory mechanisms of Gq-signaling pathways
maxDepth	4
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	G alpha (q) signalling events
orthologousEvent	[Pathway:R-MMU-416476] G alpha (q) signalling events - Mus musculus [Pathway:R-RNO-416476] G alpha (q) signalling events - Rattus norvegicus [Pathway:R-CFA-416476] G alpha (q) signalling events - Canis familiaris [Pathway:R-BTA-416476] G alpha (q) signalling events - Bos taurus [Pathway:R-SSC-416476] G alpha (q) signalling events - Sus scrofa [Pathway:R-DRE-416476] G alpha (q) signalling events - Danio rerio [Pathway:R-XTR-416476] G alpha (q) signalling events - Xenopus tropicalis [Pathway:R-GGA-416476] G alpha (q) signalling events - Gallus gallus [Pathway:R-DME-416476] G alpha (q) signalling events - Drosophila melanogaster [Pathway:R-CEL-416476] G alpha (q) signalling events - Caenorhabditis elegans [Pathway:R-SPO-416476] G alpha (q) signalling events - Schizosaccharomyces pombe [Pathway:R-SCE-416476] G alpha (q) signalling events - Saccharomyces cerevisiae [Pathway:R-DDI-416476] G alpha (q) signalling events - Dictyostelium discoideum [Pathway:R-PFA-416476] G alpha (q) signalling events - Plasmodium falciparum
releaseDate	2009-09-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:425201] Akkerman, JW, 2009-06-03
revised	[InstanceEdit:9012014] Varusai, Thawfeek, 2017-07-10
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-416476
summation	[Summation:397840] The classic signalling route for G alpha (q) is activation o...
updateTrackers	[UpdateTracker:9791401] Update Tracker - [Pathway:416476] G alpha (q) signalling events - v30:[addHasEvent, addLiteratureReference, modifyText, updateContainedPathway, updateContainedRLE] [UpdateTracker:9790958] Update Tracker - [Pathway:416476] G alpha (q) signalling events - v32:[addHasEvent, updateContainedPathway, updateContainedRLE, updateIndirectRLE] [UpdateTracker:9784500] Update Tracker - [Pathway:416476] G alpha (q) signalling events - v54:[updateContainedPathway] [UpdateTracker:9790595] Update Tracker - [Pathway:416476] G alpha (q) signalling events - v33:[addHasEvent, updateContainedPathway, updateContainedRLE] [UpdateTracker:9787859] Update Tracker - [Pathway:416476] G alpha (q) signalling events - v44:[updateContainedRLE] [UpdateTracker:9790234] Update Tracker - [Pathway:416476] G alpha (q) signalling events - v34:[updateContainedPathway, updateContainedRLE] [UpdateTracker:9788957] Update Tracker - [Pathway:416476] G alpha (q) signalling events - v39:[updateContainedPathway] [UpdateTracker:9778861] Update Tracker - [Pathway:416476] G alpha (q) signalling events - v67:[addHasEvent, updateIndirectRLE] [UpdateTracker:9780873] Update Tracker - [Pathway:416476] G alpha (q) signalling events - v62:[modifyText] [UpdateTracker:9780464] Update Tracker - [Pathway:416476] G alpha (q) signalling events - v63:[addHasEvent, updateContainedPathway] [UpdateTracker:9782513] Update Tracker - [Pathway:416476] G alpha (q) signalling events - v59:[updateIndirectRLE] [UpdateTracker:9789791] Update Tracker - [Pathway:416476] G alpha (q) signalling events - v37:[updateIndirectRLE] [UpdateTracker:9781472] Update Tracker - [Pathway:416476] G alpha (q) signalling events - v61:[updateContainedRLE] [UpdateTracker:9863968] Update Tracker - [Pathway:416476] G alpha (q) signalling events - v88:[updateIndirectRLE] [UpdateTracker:9846634] Update Tracker - [Pathway:416476] G alpha (q) signalling events - v84:[updateIndirectRLE] [UpdateTracker:9789203] Update Tracker - [Pathway:416476] G alpha (q) signalling events - v38:[updateContainedPathway] [UpdateTracker:9788752] Update Tracker - [Pathway:416476] G alpha (q) signalling events - v40:[updateContainedPathway]

Referrals

(hasEvent)	[Pathway:R-HSA-388396] GPCR downstream signalling
(hasEncapsulatedEvent)	[Pathway:R-HSA-881907] Gastrin-CREB signalling pathway via PKC and MAPK [Pathway:R-HSA-373076] Class A/1 (Rhodopsin-like receptors) [Pathway:R-HSA-420499] Class C/3 (Metabotropic glutamate/pheromone receptors) [Pathway:R-HSA-373080] Class B/2 (Secretin family receptors)
(updatedInstance)	[UpdateTracker:9791401] Update Tracker - [Pathway:416476] G alpha (q) signalling events - v30:[addHasEvent, addLiteratureReference, modifyText, updateContainedPathway, updateContainedRLE] [UpdateTracker:9790958] Update Tracker - [Pathway:416476] G alpha (q) signalling events - v32:[addHasEvent, updateContainedPathway, updateContainedRLE, updateIndirectRLE] [UpdateTracker:9784500] Update Tracker - [Pathway:416476] G alpha (q) signalling events - v54:[updateContainedPathway] [UpdateTracker:9790595] Update Tracker - [Pathway:416476] G alpha (q) signalling events - v33:[addHasEvent, updateContainedPathway, updateContainedRLE] [UpdateTracker:9787859] Update Tracker - [Pathway:416476] G alpha (q) signalling events - v44:[updateContainedRLE] [UpdateTracker:9790234] Update Tracker - [Pathway:416476] G alpha (q) signalling events - v34:[updateContainedPathway, updateContainedRLE] [UpdateTracker:9788957] Update Tracker - [Pathway:416476] G alpha (q) signalling events - v39:[updateContainedPathway] [UpdateTracker:9778861] Update Tracker - [Pathway:416476] G alpha (q) signalling events - v67:[addHasEvent, updateIndirectRLE] [UpdateTracker:9780873] Update Tracker - [Pathway:416476] G alpha (q) signalling events - v62:[modifyText] [UpdateTracker:9780464] Update Tracker - [Pathway:416476] G alpha (q) signalling events - v63:[addHasEvent, updateContainedPathway] [UpdateTracker:9782513] Update Tracker - [Pathway:416476] G alpha (q) signalling events - v59:[updateIndirectRLE] [UpdateTracker:9789791] Update Tracker - [Pathway:416476] G alpha (q) signalling events - v37:[updateIndirectRLE] [UpdateTracker:9781472] Update Tracker - [Pathway:416476] G alpha (q) signalling events - v61:[updateContainedRLE] [UpdateTracker:9863968] Update Tracker - [Pathway:416476] G alpha (q) signalling events - v88:[updateIndirectRLE] [UpdateTracker:9846634] Update Tracker - [Pathway:416476] G alpha (q) signalling events - v84:[updateIndirectRLE] [UpdateTracker:9789203] Update Tracker - [Pathway:416476] G alpha (q) signalling events - v38:[updateContainedPathway] [UpdateTracker:9788752] Update Tracker - [Pathway:416476] G alpha (q) signalling events - v40:[updateContainedPathway]

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