Reactome | Pyrimidine catabolism

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Pyrimidine catabolism Show undefined attributes

authored	[InstanceEdit:73449] Jassal, B, 2003-06-17 09:00:26
created	[InstanceEdit:73446] Jassal, B, 2003-06-17 09:00:25
dbId	73621
deleted	[Deleted:500469] Deletion of instance: 112223 [Deleted:500468] Deletion of instances: 112260, 112222 [Deleted:500423] Deletion of instance: 109312 [Deleted:8959453] Deletion of instance: 73848
displayName	Pyrimidine catabolism
eventOf	[Pathway:R-HSA-8956319] Nucleotide catabolism - Homo sapiens
figure	[Figure:74272] /figures/pyrimidine_catabolism.jpg
goBiologicalProcess	[GO_BiologicalProcess:6248] pyrimidine nucleoside catabolic process
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-109514] TMP, (d)UMP, uridine 2' monophosphate, or uridine 3'-monophosphate + H2O => thymidine, deoxyuridine, or uridine + orthophosphate [NT5M] - Homo sapiens [Reaction:R-HSA-109291] CMP or TMP or UMP + H2O => cytidine, thymidine, or uridine + orthophosphate [NT5E] - Homo sapiens [Reaction:R-HSA-109449] (d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3) - Homo sapiens [Reaction:R-HSA-109380] (d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A) - Homo sapiens [Reaction:R-HSA-109480] TMP, uridine 2', 3', or 5' monophosphates, or deoxyuridine 3' or 5' monophosphates + H2O => thymidine or (deoxy)uridine + orthophosphate [NT5C] - Homo sapiens [Reaction:R-HSA-74376] (deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP) - Homo sapiens [Reaction:R-HSA-112265] thymidine or deoxyuridine + orthophosphate <=> thymine or uracil + 2-deoxy-D-ribose 1-phosphate [TYMP] - Homo sapiens [Reaction:R-HSA-73585] reduction of uracil to form dihydrouracil - Homo sapiens [Reaction:R-HSA-73589] conversion of 5,6-dihydrouracil to 3-ureidopropionate - Homo sapiens [Reaction:R-HSA-73591] conversion of 3-ureidopropionate to beta-alanine - Homo sapiens [BlackBoxEvent:R-HSA-909765] Mitochondrial uptake of beta-alanine - Homo sapiens [Reaction:R-HSA-909776] beta-alanine + pyruvate => 3-oxopropanoate + alanine - Homo sapiens [Reaction:R-HSA-73616] reduction of thymine to form 5,6-Dihydrothymine - Homo sapiens [Reaction:R-HSA-73618] conversion of 5,6-Dihydrothymine to 3-Ureidoisobutyrate - Homo sapiens [Reaction:R-HSA-73620] conversion of 3-Ureidoiosbutyrate to 3-Aminoisobutyrate - Homo sapiens [BlackBoxEvent:R-HSA-909755] Mitochondrial uptake of (R)-3-aminoisobutyric acid - Homo sapiens [Reaction:R-HSA-909780] (R)-3-amino-2-methylpropanoate + pyruvate => 2-methyl-3-oxopropanoate + L-alanine - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2021-09-15
literatureReference	[LiteratureReference:84017] Beta-amino acids: mammalian metabolism and utility as alpha-amino acid analogues [LiteratureReference:909759] Purification, properties, and sequencing of aminoisobutyrate aminotransferases from rat liver
maxDepth	2
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	Pyrimidine catabolism
orthologousEvent	[Pathway:R-MMU-73621] Pyrimidine catabolism - Mus musculus [Pathway:R-RNO-73621] Pyrimidine catabolism - Rattus norvegicus [Pathway:R-CFA-73621] Pyrimidine catabolism - Canis familiaris [Pathway:R-BTA-73621] Pyrimidine catabolism - Bos taurus [Pathway:R-SSC-73621] Pyrimidine catabolism - Sus scrofa [Pathway:R-DRE-73621] Pyrimidine catabolism - Danio rerio [Pathway:R-XTR-73621] Pyrimidine catabolism - Xenopus tropicalis [Pathway:R-GGA-73621] Pyrimidine catabolism - Gallus gallus [Pathway:R-DME-73621] Pyrimidine catabolism - Drosophila melanogaster [Pathway:R-CEL-73621] Pyrimidine catabolism - Caenorhabditis elegans [Pathway:R-DDI-73621] Pyrimidine catabolism - Dictyostelium discoideum [Pathway:R-PFA-73621] Pyrimidine catabolism - Plasmodium falciparum
releaseDate	2004-07-06
releaseStatus	UPDATED
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:504064] D'Eustachio, P, 2010-02-05
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-73621
summation	[Summation:73837] In parallel sequences of three reactions each, thymine is co...
updateTrackers	[UpdateTracker:9790289] Update Tracker - [Pathway:73621] Pyrimidine catabolism - v34:[addLiteratureReference, modifyText, updateContainedRLE] [UpdateTracker:9790764] Update Tracker - [Pathway:73621] Pyrimidine catabolism - v33:[updateContainedRLE] [UpdateTracker:9781261] Update Tracker - [Pathway:73621] Pyrimidine catabolism - v61:[updateContainedRLE] [UpdateTracker:9789960] Update Tracker - [Pathway:73621] Pyrimidine catabolism - v36:[updateContainedRLE] [UpdateTracker:9775592] Update Tracker - [Pathway:73621] Pyrimidine catabolism - v78:[updateContainedRLE] [UpdateTracker:9792230] Update Tracker - [Pathway:73621] Pyrimidine catabolism - v22:[updateContainedRLE] [UpdateTracker:9791054] Update Tracker - [Pathway:73621] Pyrimidine catabolism - v32:[addHasEvent, updateContainedRLE] [UpdateTracker:9790118] Update Tracker - [Pathway:73621] Pyrimidine catabolism - v35:[addHasEvent, modifyText, updateContainedRLE] [UpdateTracker:9781833] Update Tracker - [Pathway:73621] Pyrimidine catabolism - v60:[removeLiteratureReference]

Referrals

(hasEvent)	[Pathway:R-HSA-8956319] Nucleotide catabolism
(replacementInstances)	[Deleted:500469] Deletion of instance: 112223 [Deleted:500423] Deletion of instance: 109312 [Deleted:8959453] Deletion of instance: 73848 [Deleted:500468] Deletion of instances: 112260, 112222
(updatedInstance)	[UpdateTracker:9790289] Update Tracker - [Pathway:73621] Pyrimidine catabolism - v34:[addLiteratureReference, modifyText, updateContainedRLE] [UpdateTracker:9790764] Update Tracker - [Pathway:73621] Pyrimidine catabolism - v33:[updateContainedRLE] [UpdateTracker:9781261] Update Tracker - [Pathway:73621] Pyrimidine catabolism - v61:[updateContainedRLE] [UpdateTracker:9789960] Update Tracker - [Pathway:73621] Pyrimidine catabolism - v36:[updateContainedRLE] [UpdateTracker:9775592] Update Tracker - [Pathway:73621] Pyrimidine catabolism - v78:[updateContainedRLE] [UpdateTracker:9792230] Update Tracker - [Pathway:73621] Pyrimidine catabolism - v22:[updateContainedRLE] [UpdateTracker:9791054] Update Tracker - [Pathway:73621] Pyrimidine catabolism - v32:[addHasEvent, updateContainedRLE] [UpdateTracker:9790118] Update Tracker - [Pathway:73621] Pyrimidine catabolism - v35:[addHasEvent, modifyText, updateContainedRLE] [UpdateTracker:9781833] Update Tracker - [Pathway:73621] Pyrimidine catabolism - v60:[removeLiteratureReference]

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