Reactome | reduction of uracil to form dihydrouracil

Schema > Reaction > Entries

reduction of uracil to form dihydrouracil Show undefined attributes

catalystActivity	[CatalystActivity:73530] dihydropyrimidine dehydrogenase (NADP+) activity of DPYD dimer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:73446] Jassal, B, 2003-06-17 09:00:25
crossReference	[DatabaseIdentifier:12667674] RHEA:18095 [DatabaseIdentifier:9976522] RHEA:18095
dbId	73585
displayName	reduction of uracil to form dihydrouracil
eventOf	[Pathway:R-HSA-73621] Pyrimidine catabolism - Homo sapiens
followingEvent	[Reaction:R-HSA-73589] conversion of 5,6-dihydrouracil to 3-ureidopropionate - Homo sapiens
input	[SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol] [SimpleEntity:R-ALL-83962] Ura [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:200230] cDNA cloning and chromosome mapping of human dihydropyrimidine dehydrogenase, an enzyme associated with 5-fluorouracil toxicity and congenital thymine uraciluria
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	reduction of uracil to form dihydrouracil uracil + NADPH + H(+) => 5,6-dihydrouracil + NADP(+)
orthologousEvent	[Reaction:R-DDI-73585] reduction of uracil to form dihydrouracil - Dictyostelium discoideum [Reaction:R-CEL-73585] reduction of uracil to form dihydrouracil - Caenorhabditis elegans [Reaction:R-DME-73585] reduction of uracil to form dihydrouracil - Drosophila melanogaster [Reaction:R-GGA-73585] reduction of uracil to form dihydrouracil - Gallus gallus [Reaction:R-XTR-73585] reduction of uracil to form dihydrouracil - Xenopus tropicalis [Reaction:R-DRE-73585] reduction of uracil to form dihydrouracil - Danio rerio [Reaction:R-SSC-73585] reduction of uracil to form dihydrouracil - Sus scrofa [Reaction:R-BTA-73585] reduction of uracil to form dihydrouracil - Bos taurus [Reaction:R-CFA-73585] reduction of uracil to form dihydrouracil - Canis familiaris [Reaction:R-RNO-73585] reduction of uracil to form dihydrouracil - Rattus norvegicus [Reaction:R-MMU-73585] reduction of uracil to form dihydrouracil - Mus musculus
output	[SimpleEntity:R-ALL-73584] 5,6-Dihydrouracil [cytosol] [SimpleEntity:R-ALL-29366] NADP+ [cytosol]
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:504064] D'Eustachio, P, 2010-02-05
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-73585
summation	[Summation:179294] Cytosolic dihydropyrimidine dehydrogenase catalyzes the reac...
updateTrackers	[UpdateTracker:9792344] Update Tracker - [Reaction:73585] uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ - v22:[addLiteratureReference, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9792344] Update Tracker - [Reaction:73585] uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ - v22:[addLiteratureReference, modifyText]
(hasEvent)	[Pathway:R-HSA-73621] Pyrimidine catabolism
(precedingEvent)	[Reaction:R-HSA-73589] conversion of 5,6-dihydrouracil to 3-ureidopropionate