Reactome | uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+

Schema > Reaction > Entries

uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ Show undefined attributes

catalystActivity	[CatalystActivity:73530] dihydropyrimidine dehydrogenase (NADP+) activity of DPYD dimer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:73446] Jassal, B, 2003-06-17 09:00:25
crossReference	[DatabaseIdentifier:11880873] Rhea:18095
dbId	73585
displayName	uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+
eventOf	[Pathway:R-HSA-73621] Pyrimidine catabolism - Homo sapiens
followingEvent	[Reaction:R-HSA-73589] 5,6-dihydrouracil + H2O => beta-ureidopropionate - Homo sapiens
input	[SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol] [SimpleEntity:R-ALL-83962] Ura [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:200230] cDNA cloning and chromosome mapping of human dihydropyrimidine dehydrogenase, an enzyme associated with 5-fluorouracil toxicity and congenital thymine uraciluria
modified	[InstanceEdit:11879863] Wright, Adam, 2024-03-11
name	uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ reduction of uracil to form dihydrouracil
orthologousEvent	[Reaction:R-DDI-73585] uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ - Dictyostelium discoideum [Reaction:R-CEL-73585] uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ - Caenorhabditis elegans [Reaction:R-DME-73585] uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ - Drosophila melanogaster [Reaction:R-GGA-73585] uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ - Gallus gallus [Reaction:R-XTR-73585] uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ - Xenopus tropicalis [Reaction:R-DRE-73585] uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ - Danio rerio [Reaction:R-SSC-73585] uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ - Sus scrofa [Reaction:R-BTA-73585] uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ - Bos taurus [Reaction:R-CFA-73585] uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ - Canis familiaris [Reaction:R-RNO-73585] uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ - Rattus norvegicus [Reaction:R-MMU-73585] uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ - Mus musculus
output	[SimpleEntity:R-ALL-73584] 5,6-Dihydrouracil [cytosol] [SimpleEntity:R-ALL-29366] NADP+ [cytosol]
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:504064] D'Eustachio, P, 2010-02-05
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-73585
summation	[Summation:179294] Cytosolic dihydropyrimidine dehydrogenase catalyzes the reac...

Referrals

(hasEvent)	[Pathway:R-HSA-73621] Pyrimidine catabolism
(precedingEvent)	[Reaction:R-HSA-73589] 5,6-dihydrouracil + H2O => beta-ureidopropionate