Reactome | (R)-3-amino-2-methylpropanoate + pyruvate => 2-methyl-3-oxopropanoate + L-alanine

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(R)-3-amino-2-methylpropanoate + pyruvate => 2-methyl-3-oxopropanoate + L-alanine Show undefined attributes

authored	[InstanceEdit:909782] D'Eustachio, P, 2010-07-07
catalystActivity	[CatalystActivity:909768] (R)-3-amino-2-methylpropionate-pyruvate transaminase activity of AGXT2 tetramer [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:909782] D'Eustachio, P, 2010-07-07
crossReference	[DatabaseIdentifier:9976518] RHEA:18394
dbId	909780
displayName	(R)-3-amino-2-methylpropanoate + pyruvate => 2-methyl-3-oxopropanoate + L-alanine
edited	[InstanceEdit:909782] D'Eustachio, P, 2010-07-07
eventOf	[Pathway:R-HSA-73621] Pyrimidine catabolism - Homo sapiens
inferredFrom	[Reaction:R-RNO-909775] (R)-3-aminoisobutyric acid + pyruvate => 2-methyl-3-oxopropanoate + alanine - Rattus norvegicus
input	[SimpleEntity:R-ALL-909779] 3AIB [mitochondrial matrix] [SimpleEntity:R-ALL-113557] PYR [mitochondrial matrix]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:904862] Human alanine-glyoxylate aminotransferase 2 lowers asymmetric dimethylarginine and protects from inhibition of nitric oxide production
maxDepth	1
modified	[InstanceEdit:9984898] Weiser, Joel, 2026-03-12
name	(R)-3-amino-2-methylpropanoate + pyruvate => 2-methyl-3-oxopropanoate + L-alanine
output	[SimpleEntity:R-ALL-9976511] 2-methyl-3-oxopropanoate [mitochondrial matrix] [SimpleEntity:R-ALL-379697] L-Ala [mitochondrial matrix]
precedingEvent	[BlackBoxEvent:R-HSA-909755] Mitochondrial uptake of (R)-3-aminoisobutyric acid - Homo sapiens
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2010-12-14
releaseStatus	UPDATED
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1004534] Jassal, B, 2010-11-09 [InstanceEdit:9977064] D'Eustachio, Peter, 2025-12-16
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-909780
summation	[Summation:909778] Mitochondrial AGXT2 tetramer catalyzes the reaction of (R)-3...
updateTrackers	[UpdateTracker:9984587] Update Tracker - [Reaction:909780] (R)-3-aminoisobutyric acid + pyruvate => 2-methyl-3-oxopropanoate + alanine - v96:[add_removeOutput]

Referrals

(updatedInstance)	[UpdateTracker:9984587] Update Tracker - [Reaction:909780] (R)-3-aminoisobutyric acid + pyruvate => 2-methyl-3-oxopropanoate + alanine - v96:[add_removeOutput]
(hasEvent)	[Pathway:R-HSA-73621] Pyrimidine catabolism
(inferredTo)	[Reaction:R-RNO-909775] (R)-3-aminoisobutyric acid + pyruvate => 2-methyl-3-oxopropanoate + alanine

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