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Schema
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Reaction
>
Entries
TMP, (d)UMP, uridine 2' monophosphate, or uridine 3'-monophosphate + H2O => thymidine, deoxyuridine, or uridine + orthophosphate [NT5M]
Show undefined attributes
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catalystActivity
[CatalystActivity:109498] 5'-nucleotidase activity of NT5M dimer [mitochondrial matrix]
catalystActivityReference
[CatalystActivityReference:9643417] 5'-nucleotidase activity of NT5M dimer [mitochondrial matrix] Human mitochondrial 5'-deoxynucleotidase. Overproduction in cultured cells and functional aspects
category
transition
compartment
[Compartment:5460] mitochondrial matrix
created
[InstanceEdit:109491] D'Eustachio, P, 2004-01-09 15:50:00
crossReference
[DatabaseIdentifier:9976510] RHEA:11081
[DatabaseIdentifier:9976527] RHEA:29360
[DatabaseIdentifier:9976500] RHEA:29356
[DatabaseIdentifier:9976502] RHEA:37356
[DatabaseIdentifier:9976504] RHEA:27891
dbId
109514
deleted
[Deleted:500424] Deletion of instances: 109517, 109516, 109515, 109505
[Deleted:500425] Deletion of instance: 109506
displayName
TMP, (d)UMP, uridine 2' monophosphate, or uridine 3'-monophosphate + H2O => thymidine, deoxyuridine, or uridine + orthophosphate [NT5M]
eventOf
[Pathway:R-HSA-73621] Pyrimidine catabolism - Homo sapiens
input
[SimpleEntity:R-ALL-113521] H2O [mitochondrial matrix]
[DefinedSet:R-ALL-500420] TMP, UMP, dU5MP, U2MP, U3MP [mitochondrial matrix]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:109489] A deoxynucleotidase in mitochondria: involvement in regulation of dNTP pools and possible link to genetic disease
[LiteratureReference:109499] Human mitochondrial 5'-deoxynucleotidase. Overproduction in cultured cells and functional aspects
[LiteratureReference:109493] Crystal structure of a human mitochondrial deoxyribonuclease
maxDepth
1
modified
[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name
TMP, (d)UMP, uridine 2' monophosphate, or uridine 3'-monophosphate + H2O => thymidine, deoxyuridine, or uridine + orthophosphate [NT5M]
dTMP + H2O => thymidine + phosphate
UMP + H2O => uridine + phosphate
dUMP + H2O => 2'-deoxyuridine + phosphate
uridine 2'-phosphate + H2O => uridine + phosphate
3'-UMP + H2O => uridine + phosphate
orthologousEvent
[Reaction:R-GGA-109514] TMP, (d)UMP, uridine 2' monophosphate, or uridine 3'-monophosphate + H2O => thymidine, deoxyuridine, or uridine + orthophosphate [NT5M] - Gallus gallus
[Reaction:R-XTR-109514] TMP, (d)UMP, uridine 2' monophosphate, or uridine 3'-monophosphate + H2O => thymidine, deoxyuridine, or uridine + orthophosphate [NT5M] - Xenopus tropicalis
[Reaction:R-SSC-109514] TMP, (d)UMP, uridine 2' monophosphate, or uridine 3'-monophosphate + H2O => thymidine, deoxyuridine, or uridine + orthophosphate [NT5M] - Sus scrofa
[Reaction:R-BTA-109514] TMP, (d)UMP, uridine 2' monophosphate, or uridine 3'-monophosphate + H2O => thymidine, deoxyuridine, or uridine + orthophosphate [NT5M] - Bos taurus
[Reaction:R-CFA-109514] TMP, (d)UMP, uridine 2' monophosphate, or uridine 3'-monophosphate + H2O => thymidine, deoxyuridine, or uridine + orthophosphate [NT5M] - Canis familiaris
[Reaction:R-RNO-109514] TMP, (d)UMP, uridine 2' monophosphate, or uridine 3'-monophosphate + H2O => thymidine, deoxyuridine, or uridine + orthophosphate [NT5M] - Rattus norvegicus
[Reaction:R-MMU-109514] TMP, (d)UMP, uridine 2' monophosphate, or uridine 3'-monophosphate + H2O => thymidine, deoxyuridine, or uridine + orthophosphate [NT5M] - Mus musculus
output
[SimpleEntity:R-ALL-113548] Pi [mitochondrial matrix]
[DefinedSet:R-ALL-500421] Thy-dRib, Ura-Rib, dU [mitochondrial matrix]
releaseDate
2004-07-06
reviewStatus
[ReviewStatus:9821382] five stars
revised
[InstanceEdit:504064] D'Eustachio, P, 2010-02-05
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-109514
summation
[Summation:178324] 5'3'-Nucleotidase, mitochondrial (NT5M) is the major nucleot...
updateTrackers
[UpdateTracker:9790998] Update Tracker - [Reaction:109514] TMP, (d)UMP, uridine 2' monophosphate, or uridine 3'-monophosphate + H2O => thymidine, deoxyuridine, or uridine + orthophosphate [NT5M] - v32:[addLiteratureReference, add_removeInput, add_removeOutput, modifyText]
Referrals
(updatedInstance)
[UpdateTracker:9790998] Update Tracker - [Reaction:109514] TMP, (d)UMP, uridine 2' monophosphate, or uridine 3'-monophosphate + H2O => thymidine, deoxyuridine, or uridine + orthophosphate [NT5M] - v32:[addLiteratureReference, add_removeInput, add_removeOutput, modifyText]
(replacementInstances)
[Deleted:500424] Deletion of instances: 109517, 109516, 109515, 109505
[Deleted:500425] Deletion of instance: 109506
(hasEvent)
[Pathway:R-HSA-73621] Pyrimidine catabolism
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