Reactome | TMP, uridine 2', 3', or 5' monophosphates, or deoxyuridine 3' or 5' monophosphates + H2O => thymidine or (deoxy)uridine + orthophosphate [NT5C]

Schema > Reaction > Entries

TMP, uridine 2', 3', or 5' monophosphates, or deoxyuridine 3' or 5' monophosphates + H2O => thymidine or (deoxy)uridine + orthophosphate [NT5C] Show undefined attributes

catalystActivity	[CatalystActivity:109469] 5'-nucleotidase activity of NT5C dimer [cytosol]
catalystActivityReference	[CatalystActivityReference:9643849] 5'-nucleotidase activity of NT5C dimer [cytosol] Cytoplasmic 5'(3')-nucleotidase from human placenta
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:109462] D'Eustachio, P, 2004-01-09 08:30:00
dbId	109480
deleted	[Deleted:500419] Deletion of instances: 109487, 109486, 109485, 109484, 109481 [Deleted:500418] Deletion of instance: 109471
displayName	TMP, uridine 2', 3', or 5' monophosphates, or deoxyuridine 3' or 5' monophosphates + H2O => thymidine or (deoxy)uridine + orthophosphate [NT5C]
eventOf	[Pathway:R-HSA-73621] Pyrimidine catabolism - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [DefinedSet:R-ALL-500414] TMP, U2MP, U3MP, UMP, dU3MP, dUMP [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:109348] Cytosolic high Km 5'-nucleotidase and 5'(3')-deoxyribonucleotidase in substrate cycles involved in nucleotide metabolism [LiteratureReference:109465] Cytoplasmic 5'(3')-nucleotidase from human placenta [LiteratureReference:109473] Mammalian 5'(3')-deoxyribonucleotidase, cDNA cloning, and overexpression of the enzyme in Escherichia coli and mammalian cells
modified	[InstanceEdit:10562314] Weiser, Joel, 2024-11-17
name	TMP, uridine 2', 3', or 5' monophosphates, or deoxyuridine 3' or 5' monophosphates + H2O => thymidine or (deoxy)uridine + orthophosphate [NT5C]
orthologousEvent	[Reaction:R-XTR-109480] TMP, uridine 2', 3', or 5' monophosphates, or deoxyuridine 3' or 5' monophosphates + H2O => thymidine or (deoxy)uridine + orthophosphate [NT5C] - Xenopus tropicalis [Reaction:R-SSC-109480] TMP, uridine 2', 3', or 5' monophosphates, or deoxyuridine 3' or 5' monophosphates + H2O => thymidine or (deoxy)uridine + orthophosphate [NT5C] - Sus scrofa [Reaction:R-BTA-109480] TMP, uridine 2', 3', or 5' monophosphates, or deoxyuridine 3' or 5' monophosphates + H2O => thymidine or (deoxy)uridine + orthophosphate [NT5C] - Bos taurus [Reaction:R-CFA-109480] TMP, uridine 2', 3', or 5' monophosphates, or deoxyuridine 3' or 5' monophosphates + H2O => thymidine or (deoxy)uridine + orthophosphate [NT5C] - Canis familiaris [Reaction:R-RNO-109480] TMP, uridine 2', 3', or 5' monophosphates, or deoxyuridine 3' or 5' monophosphates + H2O => thymidine or (deoxy)uridine + orthophosphate [NT5C] - Rattus norvegicus [Reaction:R-MMU-109480] TMP, uridine 2', 3', or 5' monophosphates, or deoxyuridine 3' or 5' monophosphates + H2O => thymidine or (deoxy)uridine + orthophosphate [NT5C] - Mus musculus
output	[SimpleEntity:R-ALL-29372] Pi [cytosol] [DefinedSet:R-ALL-500415] Thy-Rib, (d)U [cytosol]
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:504064] D'Eustachio, P, 2010-02-05
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-109480
summation	[Summation:178313] Cytosolic 5'3'-nucleotidase (NT5C) catalyzes the hydrolysis ...
updateTrackers	[UpdateTracker:9791050] Update Tracker - [Reaction:109480] TMP, uridine 2', 3', or 5' monophosphates, or deoxyuridine 3' or 5' monophosphates + H2O => thymidine or (deoxy)uridine + orthophosphate [NT5C] - v32:[addLiteratureReference, add_removeInput, add_removeOutput, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9791050] Update Tracker - [Reaction:109480] TMP, uridine 2', 3', or 5' monophosphates, or deoxyuridine 3' or 5' monophosphates + H2O => thymidine or (deoxy)uridine + orthophosphate [NT5C] - v32:[addLiteratureReference, add_removeInput, add_removeOutput, modifyText]
(replacementInstances)	[Deleted:500419] Deletion of instances: 109487, 109486, 109485, 109484, 109481 [Deleted:500418] Deletion of instance: 109471
(hasEvent)	[Pathway:R-HSA-73621] Pyrimidine catabolism