Reactome | reduction of thymine to form 5,6-Dihydrothymine

Schema > Reaction > Entries

reduction of thymine to form 5,6-Dihydrothymine Show undefined attributes

catalystActivity	[CatalystActivity:73530] dihydropyrimidine dehydrogenase (NADP+) activity of DPYD dimer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:73446] Jassal, B, 2003-06-17 09:00:25
crossReference	[DatabaseIdentifier:12667801] RHEA:58286 [DatabaseIdentifier:9976497] RHEA:58286
dbId	73616
displayName	reduction of thymine to form 5,6-Dihydrothymine
eventOf	[Pathway:R-HSA-73621] Pyrimidine catabolism - Homo sapiens
followingEvent	[Reaction:R-HSA-73618] conversion of 5,6-Dihydrothymine to 3-Ureidoisobutyrate - Homo sapiens
input	[SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol] [SimpleEntity:R-ALL-83960] Thy [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:200230] cDNA cloning and chromosome mapping of human dihydropyrimidine dehydrogenase, an enzyme associated with 5-fluorouracil toxicity and congenital thymine uraciluria
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	reduction of thymine to form 5,6-Dihydrothymine thymine + NADPH + H(+) => 5,6-dihydrothymine + NADP(+)
orthologousEvent	[Reaction:R-DDI-73616] reduction of thymine to form 5,6-Dihydrothymine - Dictyostelium discoideum [Reaction:R-CEL-73616] reduction of thymine to form 5,6-Dihydrothymine - Caenorhabditis elegans [Reaction:R-DME-73616] reduction of thymine to form 5,6-Dihydrothymine - Drosophila melanogaster [Reaction:R-GGA-73616] reduction of thymine to form 5,6-Dihydrothymine - Gallus gallus [Reaction:R-XTR-73616] reduction of thymine to form 5,6-Dihydrothymine - Xenopus tropicalis [Reaction:R-DRE-73616] reduction of thymine to form 5,6-Dihydrothymine - Danio rerio [Reaction:R-SSC-73616] reduction of thymine to form 5,6-Dihydrothymine - Sus scrofa [Reaction:R-BTA-73616] reduction of thymine to form 5,6-Dihydrothymine - Bos taurus [Reaction:R-CFA-73616] reduction of thymine to form 5,6-Dihydrothymine - Canis familiaris [Reaction:R-RNO-73616] reduction of thymine to form 5,6-Dihydrothymine - Rattus norvegicus [Reaction:R-MMU-73616] reduction of thymine to form 5,6-Dihydrothymine - Mus musculus
output	[SimpleEntity:R-ALL-73541] 5,6-Dihydrothymine [cytosol] [SimpleEntity:R-ALL-29366] NADP+ [cytosol]
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:504064] D'Eustachio, P, 2010-02-05
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-73616
summation	[Summation:179234] Cytosolic dihydropyrimidine dehydrogenase catalyzes the reac...
updateTrackers	[UpdateTracker:9792237] Update Tracker - [Reaction:73616] thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ - v22:[addLiteratureReference, modifyText] [UpdateTracker:9790654] Update Tracker - [Reaction:73616] thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ - v33:[add_removeCatalystActivity]

Referrals

(updatedInstance)	[UpdateTracker:9792237] Update Tracker - [Reaction:73616] thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ - v22:[addLiteratureReference, modifyText] [UpdateTracker:9790654] Update Tracker - [Reaction:73616] thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ - v33:[add_removeCatalystActivity]
(precedingEvent)	[Reaction:R-HSA-73618] conversion of 5,6-Dihydrothymine to 3-Ureidoisobutyrate
(hasEvent)	[Pathway:R-HSA-73621] Pyrimidine catabolism