In parallel sequences of three reactions each, thymine is co...

created [InstanceEdit:73449] Jassal, B, 2003-06-17 09:00:26
dbId 73837
displayName In parallel sequences of three reactions each, thymine is co...
modified [InstanceEdit:996686] D'Eustachio, P, 2010-11-07
schemaClass Summation
text In parallel sequences of three reactions each, thymine is converted to beta-aminoisobutyrate and uracil is converted to beta-alanine. Both of these molecules are excreted in human urine and appear to be normal end products of pyrimidine catabolism (Griffith 1986; Webster et al. 2001). Mitochondrial AGXT2, however, can also catalyze the transamination of both molecules with pyruvate, yielding 2-oxoacids that can be metabolized further by reactions of branched-chain amino acid and short-chain fatty acid catabolism (Tamaki et al. 2000). The importance of these reactions in normal human pyrimidine catabolism has not been well worked out.
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