Reactome | EIF4G1 [cytosol]

Schema > EntityWithAccessionedSequence > Entries

EIF4G1 [cytosol] Show undefined attributes

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-HSA-927743] mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] - Homo sapiens [Complex:R-HSA-429977] Translatable mRNA Complex [cytosol] - Homo sapiens [Complex:R-HSA-450623] AUF1 Complexed with Translation and Heat Shock Proteins [cytosol] - Homo sapiens [Complex:R-HSA-927845] mRNA Cleaved by SMG6 [cytosol] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-165766] Phosphorylation and activation of eIF4G by activated S6K1 - Homo sapiens [Reaction:R-HSA-72631] Formation of the cap-binding eIF4F complex - Homo sapiens [Reaction:R-HSA-450551] AUF1 binds translation and heat shock proteins - Homo sapiens [BlackBoxEvent:R-HSA-9014610] Translation of ROBO3.2 mRNA initiates NMD - Homo sapiens
dbId	72584
displayName	EIF4G1 [cytosol]
endCoordinate	1599
inDisease	false
inferredTo	[EntityWithAccessionedSequence:R-MMU-72584] Eif4g1 [cytosol] - Mus musculus [EntityWithAccessionedSequence:R-RNO-72584] EIF4G1 [cytosol] - Rattus norvegicus [EntityWithAccessionedSequence:R-CFA-72584] EIF4G1 [cytosol] - Canis familiaris [EntityWithAccessionedSequence:R-BTA-72584] EIF4G1 [cytosol] - Bos taurus [EntityWithAccessionedSequence:R-SSC-72584] EIF4G1 [cytosol] - Sus scrofa [GenomeEncodedEntity:R-DRE-72584] Ghost homologue of EIF4G1 [cytosol] - Danio rerio [EntityWithAccessionedSequence:R-XTR-72584] eif4g1 [cytosol] - Xenopus tropicalis [EntityWithAccessionedSequence:R-GGA-72584] EIF4G1 [cytosol] - Gallus gallus [EntityWithAccessionedSequence:R-DME-72584] eIF4G1 [cytosol] - Drosophila melanogaster [EntityWithAccessionedSequence:R-CEL-72584] ifg-1 [cytosol] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-DDI-72584] eif4g [cytosol] - Dictyostelium discoideum [EntityWithAccessionedSequence:R-SPO-72584] tif471 [cytosol] - Schizosaccharomyces pombe [EntityWithAccessionedSequence:R-SCE-72584] TIF4631 [cytosol] - Saccharomyces cerevisiae [EntityWithAccessionedSequence:R-SCE-72584-2] TIF4632 [cytosol] - Saccharomyces cerevisiae [DefinedSet:R-SCE-72584-3] Homologues of EIF4G1 [cytosol] - Saccharomyces cerevisiae [EntityWithAccessionedSequence:R-PFA-72584] EIF4G1 [cytosol] - Plasmodium falciparum [EntityWithAccessionedSequence:R-PFA-72584-2] EIF4G1 [cytosol] - Plasmodium falciparum [DefinedSet:R-PFA-72584-3] Homologues of EIF4G1 [cytosol] - Plasmodium falciparum
maxDepth	1
memberOf	[DefinedSet:R-HSA-1678828] EIF4G [cytosol] - Homo sapiens
modified	[InstanceEdit:3322334] Wu, G, 2013-05-03
name	EIF4G1 eIF4G eIF-4-gamma eIF-4G eukaryotic translation initiation factor 4 gamma P220 Eukaryotic translation initiation factor 4 gamma p220
producedByEvent	[BlackBoxEvent:R-HSA-927830] Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex - Homo sapiens [Reaction:R-HSA-429992] PARN deadenylates mRNA - Homo sapiens [Reaction:R-HSA-429955] CCR4-NOT complex deadenylates mRNA - Homo sapiens [Reaction:R-HSA-72619] eIF2:GTP is hydrolyzed, eIFs are released - Homo sapiens
referenceEntity	[ReferenceGeneProduct:uniprot:Q04637] UniProt:Q04637 EIF4G1
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-72584
startCoordinate	1
updateTrackers	[UpdateTracker:9877984] Update Tracker - [EntityWithAccessionedSequence:72584] EIF4G1 [cytosol] - v44:[modifyEndCoordinate] [UpdateTracker:9880921] Update Tracker - [EntityWithAccessionedSequence:72584] EIF4G1 [cytosol] - v45:[addName]

Referrals

(updatedInstance)	[UpdateTracker:9877984] Update Tracker - [EntityWithAccessionedSequence:72584] EIF4G1 [cytosol] - v44:[modifyEndCoordinate] [UpdateTracker:9880921] Update Tracker - [EntityWithAccessionedSequence:72584] EIF4G1 [cytosol] - v45:[addName]
(hasComponent)	[Complex:R-HSA-450623] AUF1 Complexed with Translation and Heat Shock Proteins [cytosol] [Complex:R-HSA-927845] mRNA Cleaved by SMG6 [cytosol] [Complex:R-HSA-927743] mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] [Complex:R-HSA-927823] mRNA Complex with a Premature Termination Codon Not Preceding an Exon Junction [cytosol] [Complex:R-HSA-9014606] ROBO3.2 mRNA:CBC:EIF4G1:PABPC1 [cytosol] [Complex:R-HSA-9822333] deadenylated mRNP regulated by BTG4 [cytosol] [Complex:R-HSA-9817647] mRNP regulated by BTG4 [cytosol] [Complex:R-HSA-8960059] Uridylated partially Deadenylated mRNA Complex [cytosol] [Complex:R-HSA-429977] Translatable mRNA Complex [cytosol] [Complex:R-HSA-429989] Partially Deadenylated mRNA Complex [cytosol] [Complex:R-HSA-72587] eIF4F [cytosol]
(input)	[Reaction:R-HSA-450551] AUF1 binds translation and heat shock proteins [BlackBoxEvent:R-HSA-9014610] Translation of ROBO3.2 mRNA initiates NMD [Reaction:R-HSA-165766] Phosphorylation and activation of eIF4G by activated S6K1 [Reaction:R-HSA-72631] Formation of the cap-binding eIF4F complex
(output)	[BlackBoxEvent:R-HSA-927830] Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex [Reaction:R-HSA-429992] PARN deadenylates mRNA [Reaction:R-HSA-429955] CCR4-NOT complex deadenylates mRNA [Reaction:R-HSA-72619] eIF2:GTP is hydrolyzed, eIFs are released
(requiredInputComponent)	[Reaction:R-HSA-156808] Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a 'closed-loop' conformation
(hasMember)	[DefinedSet:R-HSA-1678828] EIF4G [cytosol]

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