Reactome | AUF1 binds translation and heat shock proteins

Schema > Reaction > Entries

AUF1 binds translation and heat shock proteins Show undefined attributes

authored	[InstanceEdit:451187] May, B, 2009-12-29
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:450588] May, B, 2009-12-16
dbId	450551
displayName	AUF1 binds translation and heat shock proteins
edited	[InstanceEdit:451187] May, B, 2009-12-29
eventOf	[Pathway:R-HSA-450408] AUF1 (hnRNP D0) binds and destabilizes mRNA - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-450580] AUF1 (hnRNP D0) is ubiquitinylated - Homo sapiens
input	[Complex:R-HSA-450598] AUF1 Tetramer: Destabilized mRNA Complex [cytosol] [EntityWithAccessionedSequence:R-HSA-72584] EIF4G1 [cytosol] [EntityWithAccessionedSequence:R-HSA-6792602] HSPA1A [cytosol] [EntityWithAccessionedSequence:R-HSA-264476] HSPA8 [cytosol] [EntityWithAccessionedSequence:R-HSA-450563] HSPB1 [cytosol] [EntityWithAccessionedSequence:R-HSA-156803] PABPC1 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:450487] Chaperone Hsp27, a novel subunit of AUF1 protein complexes, functions in AU-rich element-mediated mRNA decay [LiteratureReference:450615] Regulation of A + U-rich element-directed mRNA turnover involving reversible phosphorylation of AUF1 [LiteratureReference:450421] Control of mRNA decay by heat shock-ubiquitin-proteasome pathway [LiteratureReference:450393] Assembly of AUF1 with eIF4G-poly(A) binding protein complex suggests a translation function in AU-rich mRNA decay
maxDepth	1
modified	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
name	AUF1 binds translation and heat shock proteins
orthologousEvent	[Reaction:R-SSC-450551] AUF1 binds translation and heat shock proteins - Sus scrofa [Reaction:R-BTA-450551] AUF1 binds translation and heat shock proteins - Bos taurus [Reaction:R-CFA-450551] AUF1 binds translation and heat shock proteins - Canis familiaris [Reaction:R-RNO-450551] AUF1 binds translation and heat shock proteins - Rattus norvegicus [Reaction:R-MMU-450551] AUF1 binds translation and heat shock proteins - Mus musculus
output	[Complex:R-HSA-450623] AUF1 Complexed with Translation and Heat Shock Proteins [cytosol]
precedingEvent	[Reaction:R-HSA-450434] AUF1(hnRNP D0) dimers bind AU-rich element in 3' UTR of mRNA - Homo sapiens
releaseDate	2010-09-21
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:882027] Wilusz, J, 2010-06-29
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-450551
summation	[Summation:451207] Tetrameric AUF1 bound to RNA forms a complex with other prot...
updateTrackers	[UpdateTracker:9784306] Update Tracker - [Reaction:450551] AUF1 binds translation and heat shock proteins - v54:[add_removeInput]

Referrals

(updatedInstance)	[UpdateTracker:9784306] Update Tracker - [Reaction:450551] AUF1 binds translation and heat shock proteins - v54:[add_removeInput]
(precedingEvent)	[BlackBoxEvent:R-HSA-450580] AUF1 (hnRNP D0) is ubiquitinylated
(hasEvent)	[Pathway:R-HSA-450408] AUF1 (hnRNP D0) binds and destabilizes mRNA