Reactome | CCR4-NOT complex deadenylates mRNA

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CCR4-NOT complex deadenylates mRNA Show undefined attributes

authored	[InstanceEdit:430015] May, B, 2009-07-22
catalystActivity	[CatalystActivity:429904] poly(A)-specific ribonuclease activity of CCR4-NOT Complex [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:429836] May, B, 2009-07-23
dbId	429955
displayName	CCR4-NOT complex deadenylates mRNA
edited	[InstanceEdit:430015] May, B, 2009-07-22
eventOf	[Pathway:R-HSA-429947] Deadenylation of mRNA - Homo sapiens
followingEvent	[Reaction:R-HSA-429978] Lsm1-7 Complex binds deadenylated mRNA - Homo sapiens [Reaction:R-HSA-430028] Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [Complex:R-HSA-429989] Partially Deadenylated mRNA Complex [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:433062] CCR4, a 3'-5' poly(A) RNA and ssDNA exonuclease, is the catalytic component of the cytoplasmic deadenylase [LiteratureReference:429874] Human Ccr4-Not complexes contain variable deadenylase subunits [LiteratureReference:433061] Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits [LiteratureReference:429957] The highways and byways of mRNA decay [LiteratureReference:429884] Concerted action of poly(A) nucleases and decapping enzyme in mammalian mRNA turnover [LiteratureReference:429929] Deadenylation is prerequisite for P-body formation and mRNA decay in mammalian cells [LiteratureReference:429946] Messenger RNA decay in mammalian cells: the exonuclease perspective [LiteratureReference:429954] The many pathways of RNA degradation [LiteratureReference:430040] From birth to death: the complex lives of eukaryotic mRNAs [LiteratureReference:429833] The enzymes and control of eukaryotic mRNA turnover [LiteratureReference:430007] The cap-to-tail guide to mRNA turnover
modified	[InstanceEdit:10560457] Wright, Adam, 2024-03-07
name	CCR4-NOT complex deadenylates mRNA
orthologousEvent	[Reaction:R-GGA-429955] CCR4-NOT complex deadenylates mRNA - Gallus gallus [Reaction:R-XTR-429955] CCR4-NOT complex deadenylates mRNA - Xenopus tropicalis [Reaction:R-SSC-429955] CCR4-NOT complex deadenylates mRNA - Sus scrofa [Reaction:R-BTA-429955] CCR4-NOT complex deadenylates mRNA - Bos taurus [Reaction:R-CFA-429955] CCR4-NOT complex deadenylates mRNA - Canis familiaris [Reaction:R-MMU-429955] CCR4-NOT complex deadenylates mRNA - Mus musculus
output	[SimpleEntity:R-ALL-76577] AMP [cytosol] [DefinedSet:R-HSA-429842] eIF4A [cytosol] [EntityWithAccessionedSequence:R-HSA-72589] EIF4B [cytosol] [EntityWithAccessionedSequence:R-HSA-72578] EIF4E [cytosol] [EntityWithAccessionedSequence:R-HSA-72584] EIF4G1 [cytosol] [OtherEntity:R-ALL-429974] mature mRNA (eukaryotic, capped and deadenylated) [cytosol] [EntityWithAccessionedSequence:R-HSA-156803] PABPC1 [cytosol] [EntityWithAccessionedSequence:R-HSA-429861] PAIP1 [cytosol]
precedingEvent	[Reaction:R-HSA-430021] PAN2-PAN3 complex partially deadenylates mRNA - Homo sapiens
releaseDate	2009-12-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:442431] Wilusz, J, 2009-09-17
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-429955
summation	[Summation:429933] The CCR4-NOT complex hydrolyzes adenosine residues at the 3'...

Referrals

(precedingEvent)	[Reaction:R-HSA-429978] Lsm1-7 Complex binds deadenylated mRNA [Reaction:R-HSA-430028] Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion
(hasEvent)	[Pathway:R-HSA-429947] Deadenylation of mRNA

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