Reactome | Phosphorylation and activation of eIF4G by activated S6K1

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Phosphorylation and activation of eIF4G by activated S6K1 Show undefined attributes

authored	[InstanceEdit:5667118] Jupe, Steve, 2015-01-23
catalystActivity	[CatalystActivity:165724] protein serine/threonine kinase activity of p-T389/412-RPS6KB1 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:165765] de Bono, B, 2005-08-09 14:41:54
dbId	165766
displayName	Phosphorylation and activation of eIF4G by activated S6K1
eventOf	[Pathway:R-HSA-166208] mTORC1-mediated signalling - Homo sapiens
input	3 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [EntityWithAccessionedSequence:R-HSA-72584] EIF4G1 [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:165184] Upstream and downstream of mTOR [LiteratureReference:9827786] Serum-stimulated, rapamycin-sensitive phosphorylation sites in the eukaryotic translation initiation factor 4GI
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	Phosphorylation and activation of eIF4G by activated S6K1
orthologousEvent	[Reaction:R-SCE-165766] Phosphorylation and activation of eIF4G by activated S6K1 - Saccharomyces cerevisiae [Reaction:R-SPO-165766] Phosphorylation and activation of eIF4G by activated S6K1 - Schizosaccharomyces pombe [Reaction:R-DDI-165766] Phosphorylation and activation of eIF4G by activated S6K1 - Dictyostelium discoideum [Reaction:R-CEL-165766] Phosphorylation and activation of eIF4G by activated S6K1 - Caenorhabditis elegans [Reaction:R-DME-165766] Phosphorylation and activation of eIF4G by activated S6K1 - Drosophila melanogaster [Reaction:R-GGA-165766] Phosphorylation and activation of eIF4G by activated S6K1 - Gallus gallus [Reaction:R-XTR-165766] Phosphorylation and activation of eIF4G by activated S6K1 - Xenopus tropicalis [Reaction:R-SSC-165766] Phosphorylation and activation of eIF4G by activated S6K1 - Sus scrofa [Reaction:R-BTA-165766] Phosphorylation and activation of eIF4G by activated S6K1 - Bos taurus [Reaction:R-CFA-165766] Phosphorylation and activation of eIF4G by activated S6K1 - Canis familiaris [Reaction:R-RNO-165766] Phosphorylation and activation of eIF4G by activated S6K1 - Rattus norvegicus [Reaction:R-MMU-165766] Phosphorylation and activation of eIF4G by activated S6K1 - Mus musculus
output	3 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [EntityWithAccessionedSequence:R-HSA-165762] p-S1108,S1148,S1192-EIF4G1 [cytosol]
precedingEvent	[Reaction:R-HSA-165718] mTORC1 phosphorylation of RPS6KB1 (S6K) - Homo sapiens
releaseDate	2005-04-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5693188] Zwartkruis, Fried J T, 2015-05-14
revised	[InstanceEdit:5687545] Jupe, Steve, 2015-04-08
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-165766
summation	[Summation:179046] Phosphorylated S6K1 in turn phosphorylates eIF4G, a componen...
updateTrackers	[UpdateTracker:9846772] Update Tracker - [Reaction:165766] Phosphorylation and activation of eIF4G by activated S6K1 - v84:[addLiteratureReference, modifyText] [UpdateTracker:9784745] Update Tracker - [Reaction:165766] Phosphorylation and activation of eIF4G by activated S6K1 - v53:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9846772] Update Tracker - [Reaction:165766] Phosphorylation and activation of eIF4G by activated S6K1 - v84:[addLiteratureReference, modifyText] [UpdateTracker:9784745] Update Tracker - [Reaction:165766] Phosphorylation and activation of eIF4G by activated S6K1 - v53:[modifyText]
(hasEvent)	[Pathway:R-HSA-166208] mTORC1-mediated signalling

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