Reactome | Formation of the cap-binding eIF4F complex

Schema > Reaction > Entries

Formation of the cap-binding eIF4F complex Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol
dbId	72631
displayName	Formation of the cap-binding eIF4F complex
eventOf	[Pathway:R-HSA-72662] Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S - Homo sapiens
followingEvent	[Reaction:R-HSA-72635] eIF4F binds to mRNP - Homo sapiens
input	[Complex:R-HSA-72576] eIF4A subunits complex [cytosol] [EntityWithAccessionedSequence:R-HSA-72578] EIF4E [cytosol] [EntityWithAccessionedSequence:R-HSA-72584] EIF4G1 [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:72632] The p46 subunit of eukaryotic initiation factor (eIF)-4F exchanges with eIF-4A
modified	[InstanceEdit:10901498] Wright, Adam, 2024-03-08
name	Formation of the cap-binding eIF4F complex
orthologousEvent	[Reaction:R-SCE-72631] Formation of the cap-binding eIF4F complex - Saccharomyces cerevisiae [Reaction:R-SPO-72631] Formation of the cap-binding eIF4F complex - Schizosaccharomyces pombe [Reaction:R-DDI-72631] Formation of the cap-binding eIF4F complex - Dictyostelium discoideum [Reaction:R-CEL-72631] Formation of the cap-binding eIF4F complex - Caenorhabditis elegans [Reaction:R-DME-72631] Formation of the cap-binding eIF4F complex - Drosophila melanogaster [Reaction:R-CFA-72631] Formation of the cap-binding eIF4F complex - Canis familiaris [Reaction:R-RNO-72631] Formation of the cap-binding eIF4F complex - Rattus norvegicus [Reaction:R-MMU-72631] Formation of the cap-binding eIF4F complex - Mus musculus
output	[Complex:R-HSA-72587] eIF4F [cytosol]
precedingEvent	[Reaction:R-HSA-72622] Release of eIF4E from the inactive eIF4E:4E-BP complex - Homo sapiens
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-72631
summation	[Summation:72634] eIF4A interacts with eIF4G, and eIF4E interacts with the ami...

Referrals

(hasEvent)	[Pathway:R-HSA-72662] Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
(precedingEvent)	[Reaction:R-HSA-72635] eIF4F binds to mRNP