Reactome | EIF4G1 [cytosol]

Schema > EntityWithAccessionedSequence > Entries

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-RNO-927743] mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] - Rattus norvegicus [Complex:R-RNO-429977] Translatable mRNA Complex [cytosol] - Rattus norvegicus [Complex:R-RNO-450623] AUF1 Complexed with Translation and Heat Shock Proteins [cytosol] - Rattus norvegicus [Complex:R-RNO-927845] mRNA Cleaved by SMG6 [cytosol] - Rattus norvegicus
consumedByEvent	[Reaction:R-RNO-165766] Phosphorylation and activation of eIF4G by activated S6K1 - Rattus norvegicus [Reaction:R-RNO-72631] Formation of the cap-binding eIF4F complex - Rattus norvegicus [Reaction:R-RNO-450551] AUF1 binds translation and heat shock proteins - Rattus norvegicus
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10106576
displayName	EIF4G1 [cytosol]
endCoordinate	1599
inDisease	false
inferredFrom	[EntityWithAccessionedSequence:R-HSA-72584] EIF4G1 [cytosol] - Homo sapiens
maxDepth	1
name	EIF4G1 M0RD03
producedByEvent	[BlackBoxEvent:R-RNO-927830] Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex - Rattus norvegicus
referenceEntity	[ReferenceGeneProduct:uniprot:M0RD03] UniProt:M0RD03
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48895] Rattus norvegicus
stId	R-RNO-72584
startCoordinate	1

(input)	[Reaction:R-RNO-450551] AUF1 binds translation and heat shock proteins [Reaction:R-RNO-165766] Phosphorylation and activation of eIF4G by activated S6K1 [Reaction:R-RNO-72631] Formation of the cap-binding eIF4F complex
(hasComponent)	[Complex:R-RNO-450623] AUF1 Complexed with Translation and Heat Shock Proteins [cytosol] [Complex:R-RNO-927845] mRNA Cleaved by SMG6 [cytosol] [Complex:R-RNO-927743] mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] [Complex:R-RNO-927823] mRNA Complex with a Premature Termination Codon Not Preceding an Exon Junction [cytosol] [Complex:R-RNO-429977] Translatable mRNA Complex [cytosol] [Complex:R-RNO-429989] Partially Deadenylated mRNA Complex [cytosol] [Complex:R-RNO-72587] eIF4F [cytosol]
(output)	[BlackBoxEvent:R-RNO-927830] Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex
(inferredTo)	[EntityWithAccessionedSequence:R-HSA-72584] EIF4G1 [cytosol]