Reactome | Hedgehog 'on' state

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Hedgehog 'on' state Show undefined attributes

authored	[InstanceEdit:5617420] Rothfels, Karen, 2014-08-06
created	[InstanceEdit:5632683] Rothfels, Karen, 2014-10-28
dbId	5632684
displayName	Hedgehog 'on' state
doi	10.3180/REACT_268718.1
edited	[InstanceEdit:5633134] Gillespie, Marc E, 2014-10-30
eventOf	[Pathway:R-HSA-5358351] Signaling by Hedgehog - Homo sapiens
hasDiagram	true
hasEHLD	false
hasEvent	[Pathway:R-HSA-5632681] Ligand-receptor interactions - Homo sapiens [Reaction:R-HSA-5632646] SMURF1/2 bind PTCH1 - Homo sapiens [Reaction:R-HSA-5632648] SMURF1/2 ubiquitinates PTCH1 - Homo sapiens [Reaction:R-HSA-5635865] SMURF1/2 dissociates from ub-PTCH1 - Homo sapiens [BlackBoxEvent:R-HSA-5632677] PTCH is internalized - Homo sapiens [BlackBoxEvent:R-HSA-5635102] GPR161 is internalized - Homo sapiens [Pathway:R-HSA-5635838] Activation of SMO - Homo sapiens [Reaction:R-HSA-5610723] GLI proteins bind SUFU - Homo sapiens [BlackBoxEvent:R-HSA-5635860] GLI:SUFU translocates to the ciliary tip in response to Hh signaling - Homo sapiens [Reaction:R-HSA-5635859] GLI:SUFU dissociates - Homo sapiens [Reaction:R-HSA-5635839] ULK3:SUFU dissociates - Homo sapiens [Reaction:R-HSA-5635842] ULK3 phosphorylates GLI - Homo sapiens [BlackBoxEvent:R-HSA-5635843] GLI translocates to the nucleus - Homo sapiens [BlackBoxEvent:R-HSA-5635841] GLI proteins are phosphorylated - Homo sapiens [Reaction:R-HSA-5635845] GLI proteins bind CDC73 - Homo sapiens [Pathway:R-HSA-5635851] GLI proteins bind promoters of Hh responsive genes to promote transcription - Homo sapiens [Reaction:R-HSA-5635855] phosphorylated GLI proteins bind SPOP:CUL3:RBX1 - Homo sapiens [Reaction:R-HSA-5635856] SPOP:CUL3:RBX1 ubiquitinates GLI2,3 - Homo sapiens [BlackBoxEvent:R-HSA-5635854] GLI2,3 are degraded by the proteasome - Homo sapiens [Reaction:R-HSA-5610735] NUMB binds ITCH - Homo sapiens [Reaction:R-HSA-5635861] NUMB:ITCH binds GLI1 - Homo sapiens [Reaction:R-HSA-5635864] NUMB:ITCH ubiquitinates GLI1 - Homo sapiens [BlackBoxEvent:R-HSA-5635868] ub-GLI is degraded by the proteasome - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5627256] Mechanisms and functions of Hedgehog signalling across the metazoa [LiteratureReference:5358245] The mechanisms of Hedgehog signalling and its roles in development and disease [LiteratureReference:5358220] Gli proteins in development and disease [LiteratureReference:5609878] The primary cilium: a signalling centre during vertebrate development
maxDepth	3
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	Hedgehog 'on' state
orthologousEvent	[Pathway:R-DME-5632684] Hedgehog 'on' state - Drosophila melanogaster [Pathway:R-DDI-5632684] Hedgehog 'on' state - Dictyostelium discoideum [Pathway:R-CEL-5632684] Hedgehog 'on' state - Caenorhabditis elegans [Pathway:R-GGA-5632684] Hedgehog 'on' state - Gallus gallus [Pathway:R-XTR-5632684] Hedgehog 'on' state - Xenopus tropicalis [Pathway:R-DRE-5632684] Hedgehog 'on' state - Danio rerio [Pathway:R-SSC-5632684] Hedgehog 'on' state - Sus scrofa [Pathway:R-BTA-5632684] Hedgehog 'on' state - Bos taurus [Pathway:R-CFA-5632684] Hedgehog 'on' state - Canis familiaris [Pathway:R-RNO-5632684] Hedgehog 'on' state - Rattus norvegicus [Pathway:R-MMU-5632684] Hedgehog 'on' state - Mus musculus
releaseDate	2014-12-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5636011] Liu, Yulu Cherry, 2014-11-09
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-5632684
summation	[Summation:5610668] Hedgehog is a secreted morphogen that has evolutionarily con...

Referrals

(hasEvent)	[Pathway:R-HSA-5358351] Signaling by Hedgehog
(hasEncapsulatedEvent)	[Pathway:R-HSA-8878166] Transcriptional regulation by RUNX2

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