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Schema
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Pathway
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Entries
Hedgehog 'on' state
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authored
[InstanceEdit:5617420] Rothfels, Karen, 2014-08-06
created
[InstanceEdit:5632683] Rothfels, Karen, 2014-10-28
dbId
5632684
displayName
Hedgehog 'on' state
doi
10.3180/REACT_268718.1
edited
[InstanceEdit:5633134] Gillespie, Marc E, 2014-10-30
eventOf
[Pathway:R-HSA-5358351] Signaling by Hedgehog - Homo sapiens
hasDiagram
true
hasEHLD
false
hasEvent
[Pathway:R-HSA-5632681] Ligand-receptor interactions - Homo sapiens
[Reaction:R-HSA-5632646] SMURF1/2 bind PTCH1 - Homo sapiens
[Reaction:R-HSA-5632648] SMURF1/2 ubiquitinates PTCH1 - Homo sapiens
[Reaction:R-HSA-5635865] SMURF1/2 dissociates from ub-PTCH1 - Homo sapiens
[BlackBoxEvent:R-HSA-5632677] PTCH is internalized - Homo sapiens
[BlackBoxEvent:R-HSA-5635102] GPR161 is internalized - Homo sapiens
[Pathway:R-HSA-5635838] Activation of SMO - Homo sapiens
[Reaction:R-HSA-5610723] GLI proteins bind SUFU - Homo sapiens
[BlackBoxEvent:R-HSA-5635860] GLI:SUFU translocates to the ciliary tip in response to Hh signaling - Homo sapiens
[Reaction:R-HSA-5635859] GLI:SUFU dissociates - Homo sapiens
[Reaction:R-HSA-5635839] ULK3:SUFU dissociates - Homo sapiens
[Reaction:R-HSA-5635842] ULK3 phosphorylates GLI - Homo sapiens
[BlackBoxEvent:R-HSA-5635843] GLI translocates to the nucleus - Homo sapiens
[BlackBoxEvent:R-HSA-5635841] GLI proteins are phosphorylated - Homo sapiens
[Reaction:R-HSA-5635845] GLI proteins bind CDC73 - Homo sapiens
[Pathway:R-HSA-5635851] GLI proteins bind promoters of Hh responsive genes to promote transcription - Homo sapiens
[Reaction:R-HSA-5635855] phosphorylated GLI proteins bind SPOP:CUL3:RBX1 - Homo sapiens
[Reaction:R-HSA-5635856] SPOP:CUL3:RBX1 ubiquitinates GLI2,3 - Homo sapiens
[BlackBoxEvent:R-HSA-5635854] GLI2,3 are degraded by the proteasome - Homo sapiens
[Reaction:R-HSA-5610735] NUMB binds ITCH - Homo sapiens
[Reaction:R-HSA-5635861] NUMB:ITCH binds GLI1 - Homo sapiens
[Reaction:R-HSA-5635864] NUMB:ITCH ubiquitinates GLI1 - Homo sapiens
[BlackBoxEvent:R-HSA-5635868] ub-GLI is degraded by the proteasome - Homo sapiens
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:5627256] Mechanisms and functions of Hedgehog signalling across the metazoa
[LiteratureReference:5358245] The mechanisms of Hedgehog signalling and its roles in development and disease
[LiteratureReference:5358220] Gli proteins in development and disease
[LiteratureReference:5609878] The primary cilium: a signalling centre during vertebrate development
maxDepth
3
modified
[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name
Hedgehog 'on' state
orthologousEvent
[Pathway:R-DME-5632684] Hedgehog 'on' state - Drosophila melanogaster
[Pathway:R-DDI-5632684] Hedgehog 'on' state - Dictyostelium discoideum
[Pathway:R-CEL-5632684] Hedgehog 'on' state - Caenorhabditis elegans
[Pathway:R-GGA-5632684] Hedgehog 'on' state - Gallus gallus
[Pathway:R-XTR-5632684] Hedgehog 'on' state - Xenopus tropicalis
[Pathway:R-DRE-5632684] Hedgehog 'on' state - Danio rerio
[Pathway:R-SSC-5632684] Hedgehog 'on' state - Sus scrofa
[Pathway:R-BTA-5632684] Hedgehog 'on' state - Bos taurus
[Pathway:R-CFA-5632684] Hedgehog 'on' state - Canis familiaris
[Pathway:R-RNO-5632684] Hedgehog 'on' state - Rattus norvegicus
[Pathway:R-MMU-5632684] Hedgehog 'on' state - Mus musculus
releaseDate
2014-12-11
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:5636011] Liu, Yulu Cherry, 2014-11-09
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-5632684
summation
[Summation:5610668] Hedgehog is a secreted morphogen that has evolutionarily con...
Referrals
(hasEvent)
[Pathway:R-HSA-5358351] Signaling by Hedgehog
(hasEncapsulatedEvent)
[Pathway:R-HSA-8878166] Transcriptional regulation by RUNX2
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