Reactome | Hedgehog 'on' state

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Hedgehog 'on' state Show undefined attributes

created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10730032
displayName	Hedgehog 'on' state
eventOf	[Pathway:R-XTR-5358351] Signaling by Hedgehog - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	true
hasEHLD	false
hasEvent	[Pathway:R-XTR-5632681] Ligand-receptor interactions - Xenopus tropicalis [Reaction:R-XTR-5635865] SMURF1/2 dissociates from ub-PTCH1 - Xenopus tropicalis [BlackBoxEvent:R-XTR-5632677] PTCH is internalized - Xenopus tropicalis [BlackBoxEvent:R-XTR-5635102] GPR161 is internalized - Xenopus tropicalis [Pathway:R-XTR-5635838] Activation of SMO - Xenopus tropicalis [Reaction:R-XTR-5610723] GLI proteins bind SUFU - Xenopus tropicalis [Reaction:R-XTR-5635859] GLI:SUFU dissociates - Xenopus tropicalis [Reaction:R-XTR-5635839] ULK3:SUFU dissociates - Xenopus tropicalis [Reaction:R-XTR-5635842] ULK3 phosphorylates GLI - Xenopus tropicalis [BlackBoxEvent:R-XTR-5635843] GLI translocates to the nucleus - Xenopus tropicalis [Reaction:R-XTR-5635845] GLI proteins bind CDC73 - Xenopus tropicalis [Reaction:R-XTR-5635855] phosphorylated GLI proteins bind SPOP:CUL3:RBX1 - Xenopus tropicalis [Reaction:R-XTR-5635856] SPOP:CUL3:RBX1 ubiquitinates GLI2,3 - Xenopus tropicalis [BlackBoxEvent:R-XTR-5635854] GLI2,3 are degraded by the proteasome - Xenopus tropicalis [Reaction:R-XTR-5610735] NUMB binds ITCH - Xenopus tropicalis [Reaction:R-XTR-5635861] NUMB:ITCH binds GLI1 - Xenopus tropicalis [Reaction:R-XTR-5635864] NUMB:ITCH ubiquitinates GLI1 - Xenopus tropicalis [BlackBoxEvent:R-XTR-5635868] ub-GLI is degraded by the proteasome - Xenopus tropicalis
inferredFrom	[Pathway:R-HSA-5632684] Hedgehog 'on' state - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	3
name	Hedgehog 'on' state
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-5632684
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-5358351] Signaling by Hedgehog
(hasEncapsulatedEvent)	[Pathway:R-XTR-8878166] Transcriptional regulation by RUNX2
(inferredTo)	[Pathway:R-HSA-5632684] Hedgehog 'on' state

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