Reactome | Activation of SMO

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Activation of SMO Show undefined attributes

authored	[InstanceEdit:5633129] Rothfels, Karen, 2014-10-29
created	[InstanceEdit:5635837] Rothfels, Karen, 2014-11-07
dbId	5635838
displayName	Activation of SMO
edited	[InstanceEdit:5633134] Gillespie, Marc E, 2014-10-30
eventOf	[Pathway:R-HSA-5632684] Hedgehog 'on' state - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-5632667] SMO dimer binds ARRB and KIF3A - Homo sapiens [BlackBoxEvent:R-HSA-5632668] SMO translocates to the cilium - Homo sapiens [Reaction:R-HSA-5632671] CSNK1A1 binds SMO dimer - Homo sapiens [Reaction:R-HSA-5632670] CSNK1A1 phosphorylates SMO dimer - Homo sapiens [Reaction:R-HSA-5632674] ADRBK1 binds phosphorylated SMO dimer - Homo sapiens [Reaction:R-HSA-5632672] ADRBK1 phosphorylates SMO dimer - Homo sapiens [Reaction:R-HSA-5633040] CSNK1A1 and ADRBK1 dissociate from p-SMO dimer - Homo sapiens [Reaction:R-HSA-5633051] EFCAB7:IQCE binds EVC2:EVC - Homo sapiens [Reaction:R-HSA-5632679] EVC2:EVC binds p-SMO - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5362322] The long-range activity of Hedgehog is regulated in the apical extracellular space by the glypican Dally and the hydrolase Notum [LiteratureReference:5358225] Hedgehog signaling in development and cancer [LiteratureReference:5617315] Divergence of hedgehog signal transduction mechanism between Drosophila and mammals [LiteratureReference:5610250] Patched acts catalytically to suppress the activity of Smoothened [LiteratureReference:208134] Signaling from Smo to Ci/Gli: conservation and divergence of Hedgehog pathways from Drosophila to vertebrates [LiteratureReference:5610259] Patched regulates Smoothened trafficking using lipoprotein-derived lipids [LiteratureReference:5610262] Patching the gaps in Hedgehog signalling [LiteratureReference:5358245] The mechanisms of Hedgehog signalling and its roles in development and disease [LiteratureReference:216183] Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothened [LiteratureReference:5610261] Patched1 regulates hedgehog signaling at the primary cilium [LiteratureReference:5609878] The primary cilium: a signalling centre during vertebrate development [LiteratureReference:5358220] Gli proteins in development and disease [LiteratureReference:216257] Hedgehog regulates smoothened activity by inducing a conformational switch [LiteratureReference:5610169] G protein-coupled receptor kinase 2 promotes high-level Hedgehog signaling by regulating the active state of Smo through kinase-dependent and kinase-independent mechanisms in Drosophila [LiteratureReference:5610283] Sonic Hedgehog dependent phosphorylation by CK1? and GRK2 is required for ciliary accumulation and activation of smoothened [LiteratureReference:208158] Hedgehog-regulated Costal2-kinase complexes control phosphorylation and proteolytic processing of Cubitus interruptus [LiteratureReference:208072] Identification of a functional interaction between the transmembrane protein Smoothened and the kinesin-related protein Costal2 [LiteratureReference:208191] Hedgehog signal transduction via Smoothened association with a cytoplasmic complex scaffolded by the atypical kinesin, Costal-2 [LiteratureReference:5610180] G-protein-coupled receptors, Hedgehog signaling and primary cilia [LiteratureReference:5628961] A Smoothened-Evc2 complex transduces the Hedgehog signal at primary cilia [LiteratureReference:5633044] Evc2 is a positive modulator of Hedgehog signalling that interacts with Evc at the cilia membrane and is also found in the nucleus [LiteratureReference:5629130] Smoothened transduces Hedgehog signal by forming a complex with Evc/Evc2 [LiteratureReference:5629111] EFCAB7 and IQCE regulate hedgehog signaling by tethering the EVC-EVC2 complex to the base of primary cilia [LiteratureReference:5635775] Hedgehog signaling and the cilium: in the zone
modified	[InstanceEdit:10655440] Wright, Adam, 2024-03-08
name	Activation of SMO
orthologousEvent	[Pathway:R-DME-5635838] Activation of SMO - Drosophila melanogaster [Pathway:R-GGA-5635838] Activation of SMO - Gallus gallus [Pathway:R-XTR-5635838] Activation of SMO - Xenopus tropicalis [Pathway:R-SSC-5635838] Activation of SMO - Sus scrofa [Pathway:R-BTA-5635838] Activation of SMO - Bos taurus [Pathway:R-CFA-5635838] Activation of SMO - Canis familiaris [Pathway:R-RNO-5635838] Activation of SMO - Rattus norvegicus [Pathway:R-MMU-5635838] Activation of SMO - Mus musculus
releaseDate	2014-12-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5636011] Liu, Yulu Cherry, 2014-11-09
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-5635838
summation	[Summation:5635819] Activation of the transmembrane protein SMO in response to H...

Referrals

(hasEvent)

[Pathway:R-HSA-5632684] Hedgehog 'on' state

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