Reactome | GLI proteins bind promoters of Hh responsive genes to promote transcription

Schema > Pathway > Entries

GLI proteins bind promoters of Hh responsive genes to promote transcription Show undefined attributes

authored	[InstanceEdit:5633210] Rothfels, Karen, 2014-10-30
created	[InstanceEdit:5635852] Rothfels, Karen, 2014-11-07
dbId	5635851
displayName	GLI proteins bind promoters of Hh responsive genes to promote transcription
edited	[InstanceEdit:5633134] Gillespie, Marc E, 2014-10-30
eventOf	[Pathway:R-HSA-5632684] Hedgehog 'on' state - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-5635848] GLI proteins bind PTCH1 gene - Homo sapiens [Reaction:R-HSA-5635846] GLI proteins bind GLI1 gene - Homo sapiens [BlackBoxEvent:R-HSA-5635853] Hh-dependent expression of GLI1 gene - Homo sapiens [Reaction:R-HSA-5635850] GLI1 binds HHIP gene, PTCH2 gene and BOC gene promoters - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5612498] The GLI gene encodes a nuclear protein which binds specific sequences in the human genome [LiteratureReference:5358220] Gli proteins in development and disease [LiteratureReference:5358245] The mechanisms of Hedgehog signalling and its roles in development and disease [LiteratureReference:5612485] Hedgehog pathway-regulated gene networks in cerebellum development and tumorigenesis [LiteratureReference:5612467] A genome-scale analysis of the cis-regulatory circuitry underlying sonic hedgehog-mediated patterning of the mammalian limb [LiteratureReference:5612477] Genomic characterization of Gli-activator targets in sonic hedgehog-mediated neural patterning [LiteratureReference:5612471] Expression of the PTCH1 tumor suppressor gene is regulated by alternative promoters and a single functional Gli-binding site [LiteratureReference:5634889] All mouse ventral spinal cord patterning by hedgehog is Gli dependent and involves an activator function of Gli3 [LiteratureReference:5609748] Gli2, but not Gli1, is required for initial Shh signaling and ectopic activation of the Shh pathway [LiteratureReference:5609839] Sonic Hedgehog-induced activation of the Gli1 promoter is mediated by GLI3 [LiteratureReference:5634901] GLI activates transcription through a herpes simplex viral protein 16-like activation domain [LiteratureReference:5634931] Mediator modulates Gli3-dependent Sonic hedgehog signaling
maxDepth	2
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	GLI proteins bind promoters of Hh responsive genes to promote transcription
releaseDate	2014-12-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5636011] Liu, Yulu Cherry, 2014-11-09
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-5635851
summation	[Summation:5635803] GLI proteins are bifunctional DNA-binding proteins that reco...

Referrals

(hasEvent)

[Pathway:R-HSA-5632684] Hedgehog 'on' state