Reactome | Ligand-receptor interactions

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Ligand-receptor interactions Show undefined attributes

authored	[InstanceEdit:5627765] Rothfels, Karen, 2014-10-20
created	[InstanceEdit:5632682] Rothfels, Karen, 2014-10-28
dbId	5632681
displayName	Ligand-receptor interactions
edited	[InstanceEdit:5633134] Gillespie, Marc E, 2014-10-30
eventOf	[Pathway:R-HSA-5632684] Hedgehog 'on' state - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-5632653] Hh-Npp binds BOC:PTCH1 - Homo sapiens [Reaction:R-HSA-5632652] Hh-Npp binds CDON and PTCH - Homo sapiens [Reaction:R-HSA-5632649] Hh-Npp binds GAS1 and PTCH - Homo sapiens [Reaction:R-HSA-445448] HHIP binds Hedgehog - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5358245] The mechanisms of Hedgehog signalling and its roles in development and disease [LiteratureReference:208217] Biochemical evidence that patched is the Hedgehog receptor [LiteratureReference:208047] Dual roles for patched in sequestering and transducing Hedgehog [LiteratureReference:208237] The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog [LiteratureReference:5610261] Patched1 regulates hedgehog signaling at the primary cilium [LiteratureReference:5610331] Vertebrate Smoothened functions at the primary cilium [LiteratureReference:5609878] The primary cilium: a signalling centre during vertebrate development [LiteratureReference:216280] The ihog cell-surface proteins bind Hedgehog and mediate pathway activation [LiteratureReference:5629107] Boc is a receptor for sonic hedgehog in the guidance of commissural axons [LiteratureReference:5629138] The cell surface membrane proteins Cdo and Boc are components and targets of the Hedgehog signaling pathway and feedback network in mice [LiteratureReference:5629141] The mode of Hedgehog binding to Ihog homologues is not conserved across different phyla [LiteratureReference:5629117] Hedgehog signaling: cooking with Gas1 [LiteratureReference:5629120] Interactions between Hedgehog proteins and their binding partners come into view [LiteratureReference:5629110] Cdon and Boc: Two transmembrane proteins implicated in cell-cell communication [LiteratureReference:5629106] Boc and Gas1 each form distinct Shh receptor complexes with Ptch1 and are required for Shh-mediated cell proliferation [LiteratureReference:5628968] All mammalian Hedgehog proteins interact with cell adhesion molecule, down-regulated by oncogenes (CDO) and brother of CDO (BOC) in a conserved manner [LiteratureReference:5629114] Gas1 extends the range of Hedgehog action by facilitating its signaling [LiteratureReference:5629126] Overlapping roles and collective requirement for the coreceptors GAS1, CDO, and BOC in SHH pathway function
maxDepth	2
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	Ligand-receptor interactions
orthologousEvent	[Pathway:R-DME-5632681] Ligand-receptor interactions - Drosophila melanogaster [Pathway:R-GGA-5632681] Ligand-receptor interactions - Gallus gallus [Pathway:R-XTR-5632681] Ligand-receptor interactions - Xenopus tropicalis [Pathway:R-DRE-5632681] Ligand-receptor interactions - Danio rerio [Pathway:R-SSC-5632681] Ligand-receptor interactions - Sus scrofa [Pathway:R-BTA-5632681] Ligand-receptor interactions - Bos taurus [Pathway:R-CFA-5632681] Ligand-receptor interactions - Canis familiaris [Pathway:R-RNO-5632681] Ligand-receptor interactions - Rattus norvegicus [Pathway:R-MMU-5632681] Ligand-receptor interactions - Mus musculus
releaseDate	2014-12-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5636011] Liu, Yulu Cherry, 2014-11-09
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-5632681
summation	[Summation:5632436] Repression of Hh signaling in the absence of ligand depends ...

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(hasEvent)

[Pathway:R-HSA-5632684] Hedgehog 'on' state

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