Reactome | NUMB:ITCH ubiquitinates GLI1

Schema > Reaction > Entries

NUMB:ITCH ubiquitinates GLI1 Show undefined attributes

authored	[InstanceEdit:5633199] Rothfels, Karen, 2014-10-30
catalystActivity	[CatalystActivity:5635830] ubiquitin protein ligase activity of GLI1:NUMB:ITCH [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:5635863] Rothfels, Karen, 2014-11-07
dbId	5635864
displayName	NUMB:ITCH ubiquitinates GLI1
edited	[InstanceEdit:5633134] Gillespie, Marc E, 2014-10-30
eventOf	[Pathway:R-HSA-5632684] Hedgehog 'on' state - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-5635868] ub-GLI is degraded by the proteasome - Homo sapiens
input	[Complex:R-HSA-5635832] GLI1:NUMB:ITCH [cytosol] [DefinedSet:R-HSA-113595] Ub [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5609710] Dual degradation signals control Gli protein stability and tumor formation [LiteratureReference:5609813] Numb activates the E3 ligase Itch to control Gli1 function through a novel degradation signal [LiteratureReference:5609824] Numb is a suppressor of Hedgehog signalling and targets Gli1 for Itch-dependent ubiquitination
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	NUMB:ITCH ubiquitinates GLI1
orthologousEvent	[Reaction:R-GGA-5635864] NUMB:ITCH ubiquitinates GLI1 - Gallus gallus [Reaction:R-XTR-5635864] NUMB:ITCH ubiquitinates GLI1 - Xenopus tropicalis [Reaction:R-DRE-5635864] NUMB:ITCH ubiquitinates GLI1 - Danio rerio [Reaction:R-SSC-5635864] NUMB:ITCH ubiquitinates GLI1 - Sus scrofa [Reaction:R-BTA-5635864] NUMB:ITCH ubiquitinates GLI1 - Bos taurus [Reaction:R-CFA-5635864] NUMB:ITCH ubiquitinates GLI1 - Canis familiaris [Reaction:R-RNO-5635864] NUMB:ITCH ubiquitinates GLI1 - Rattus norvegicus [Reaction:R-MMU-5635864] NUMB:ITCH ubiquitinates GLI1 - Mus musculus
output	[Complex:R-HSA-5635836] ub-GLI1:NUMB:ITCH [cytosol]
precedingEvent	[Reaction:R-HSA-5635861] NUMB:ITCH binds GLI1 - Homo sapiens
releaseDate	2014-12-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5636011] Liu, Yulu Cherry, 2014-11-09
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5635864
summation	[Summation:5635795] GLI1 is ubiquitinated by ITCH and subsequently degraded by t...

Referrals

(hasEvent)	[Pathway:R-HSA-5632684] Hedgehog 'on' state
(precedingEvent)	[BlackBoxEvent:R-HSA-5635868] ub-GLI is degraded by the proteasome