Reactome | GLI:SUFU dissociates

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GLI:SUFU dissociates Show undefined attributes

authored	[InstanceEdit:5633210] Rothfels, Karen, 2014-10-30
category	dissociation
compartment	[Compartment:5263228] ciliary tip
created	[InstanceEdit:5635858] Rothfels, Karen, 2014-11-07
dbId	5635859
displayName	GLI:SUFU dissociates
edited	[InstanceEdit:5633134] Gillespie, Marc E, 2014-10-30
eventOf	[Pathway:R-HSA-5632684] Hedgehog 'on' state - Homo sapiens
followingEvent	[Reaction:R-HSA-5635842] ULK3 phosphorylates GLI - Homo sapiens
input	[Complex:R-HSA-5621783] GLI:SUFU [ciliary tip]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5609873] The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins [LiteratureReference:5609686] A mechanism for vertebrate Hedgehog signaling: recruitment to cilia and dissociation of SuFu-Gli protein complexes [LiteratureReference:5609843] Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation [LiteratureReference:5610185] Gli2 trafficking links Hedgehog-dependent activation of Smoothened in the primary cilium to transcriptional activation in the nucleus [LiteratureReference:5609775] Kinetics of hedgehog-dependent full-length Gli3 accumulation in primary cilia and subsequent degradation [LiteratureReference:5610269] Protein kinase A acts at the basal body of the primary cilium to prevent Gli2 activation and ventralization of the mouse neural tube [LiteratureReference:5634948] Sonic-hedgehog-mediated proliferation requires the localization of PKA to the cilium base [LiteratureReference:5358245] The mechanisms of Hedgehog signalling and its roles in development and disease [LiteratureReference:5610304] TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary cilia [LiteratureReference:5610306] The ciliary G-protein-coupled receptor Gpr161 negatively regulates the Sonic hedgehog pathway via cAMP signaling [LiteratureReference:5610180] G-protein-coupled receptors, Hedgehog signaling and primary cilia
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	GLI:SUFU dissociates
orthologousEvent	[Reaction:R-GGA-5635859] GLI:SUFU dissociates - Gallus gallus [Reaction:R-XTR-5635859] GLI:SUFU dissociates - Xenopus tropicalis [Reaction:R-SSC-5635859] GLI:SUFU dissociates - Sus scrofa [Reaction:R-BTA-5635859] GLI:SUFU dissociates - Bos taurus [Reaction:R-CFA-5635859] GLI:SUFU dissociates - Canis familiaris [Reaction:R-RNO-5635859] GLI:SUFU dissociates - Rattus norvegicus [Reaction:R-MMU-5635859] GLI:SUFU dissociates - Mus musculus
output	[DefinedSet:R-HSA-5621782] GLI1,2,3 [ciliary tip] [EntityWithAccessionedSequence:R-HSA-5610426] SUFU [ciliary tip]
precedingEvent	[BlackBoxEvent:R-HSA-5635860] GLI:SUFU translocates to the ciliary tip in response to Hh signaling - Homo sapiens
regulatedBy	[Requirement:R-HSA-5635876] Requirement by 'p6S, T-SMO dimer:EVC2:EVC [ciliary membrane]'
releaseDate	2014-12-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5636011] Liu, Yulu Cherry, 2014-11-09
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5635859
summation	[Summation:5635789] Hh signaling promotes the dissociation of the GLI:SUFU compl...

Referrals

(hasEvent)	[Pathway:R-HSA-5632684] Hedgehog 'on' state
(precedingEvent)	[Reaction:R-HSA-5635842] ULK3 phosphorylates GLI

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