Reactome | SMURF1/2 ubiquitinates PTCH1

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SMURF1/2 ubiquitinates PTCH1 Show undefined attributes

authored	[InstanceEdit:5627765] Rothfels, Karen, 2014-10-20
catalystActivity	[CatalystActivity:5632637] ubiquitin protein ligase activity of PTCH1:SMURF [ciliary membrane]
category	transition
compartment	[Compartment:261122] ciliary membrane
created	[InstanceEdit:5632647] Rothfels, Karen, 2014-10-28
dbId	5632648
displayName	SMURF1/2 ubiquitinates PTCH1
edited	[InstanceEdit:5633134] Gillespie, Marc E, 2014-10-30
eventOf	[Pathway:R-HSA-5632684] Hedgehog 'on' state - Homo sapiens
followingEvent	[Reaction:R-HSA-5635865] SMURF1/2 dissociates from ub-PTCH1 - Homo sapiens
inferredFrom	[Reaction:R-MMU-5632644] Smurf1/2 ubiquitinates Ptch1 - Mus musculus
input	[Complex:R-HSA-5632594] PTCH1:SMURF [ciliary membrane] [DefinedSet:R-HSA-113595] Ub [cytosol]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:5610261] Patched1 regulates hedgehog signaling at the primary cilium [LiteratureReference:5618035] Requirement of Smurf-mediated endocytosis of Patched1 in Sonic Hedgehog signal reception [LiteratureReference:5618032] Activation of Smurf E3 ligase promoted by smoothened regulates hedgehog signaling through targeting patched turnover
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	SMURF1/2 ubiquitinates PTCH1
output	[Complex:R-HSA-5632582] ub-PTCH1:SMURF [ciliary membrane]
precedingEvent	[Reaction:R-HSA-5632646] SMURF1/2 bind PTCH1 - Homo sapiens
releaseDate	2014-12-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5636011] Liu, Yulu Cherry, 2014-11-09
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5632648
summation	[Summation:5632439] SMURF 1 and 2 are required in a redundant manner for the lig...

Referrals

(hasEvent)	[Pathway:R-HSA-5632684] Hedgehog 'on' state
(precedingEvent)	[Reaction:R-HSA-5635865] SMURF1/2 dissociates from ub-PTCH1
(inferredTo)	[Reaction:R-MMU-5632644] Smurf1/2 ubiquitinates Ptch1

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