Reactome | Hedgehog 'on' state

Schema > Pathway > Entries

created	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
dbId	11050486
displayName	Hedgehog 'on' state
eventOf	[Pathway:R-DDI-5358351] Signaling by Hedgehog - Dictyostelium discoideum
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-DDI-5635856] SPOP:CUL3:RBX1 ubiquitinates GLI2,3 - Dictyostelium discoideum [BlackBoxEvent:R-DDI-5635854] GLI2,3 are degraded by the proteasome - Dictyostelium discoideum
inferredFrom	[Pathway:R-HSA-5632684] Hedgehog 'on' state - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Hedgehog 'on' state
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:170941] Dictyostelium discoideum
stId	R-DDI-5632684
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-DDI-5358351] Signaling by Hedgehog
(inferredTo)	[Pathway:R-HSA-5632684] Hedgehog 'on' state