Reactome | GPR161 is internalized

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GPR161 is internalized Show undefined attributes

authored	[InstanceEdit:5633210] Rothfels, Karen, 2014-10-30
category	omitted
compartment	[Compartment:261122] ciliary membrane [Compartment:24337] endocytic vesicle membrane
created	[InstanceEdit:5635101] Rothfels, Karen, 2014-11-06
dbId	5635102
displayName	GPR161 is internalized
edited	[InstanceEdit:5633134] Gillespie, Marc E, 2014-10-30
eventOf	[Pathway:R-HSA-5632684] Hedgehog 'on' state - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-5610373] GPR161 [ciliary membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5610261] Patched1 regulates hedgehog signaling at the primary cilium [LiteratureReference:5610304] TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary cilia [LiteratureReference:5610306] The ciliary G-protein-coupled receptor Gpr161 negatively regulates the Sonic hedgehog pathway via cAMP signaling [LiteratureReference:5609873] The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins [LiteratureReference:5609686] A mechanism for vertebrate Hedgehog signaling: recruitment to cilia and dissociation of SuFu-Gli protein complexes [LiteratureReference:5610180] G-protein-coupled receptors, Hedgehog signaling and primary cilia
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	GPR161 is internalized
orthologousEvent	[BlackBoxEvent:R-GGA-5635102] GPR161 is internalized - Gallus gallus [BlackBoxEvent:R-XTR-5635102] GPR161 is internalized - Xenopus tropicalis [BlackBoxEvent:R-DRE-5635102] GPR161 is internalized - Danio rerio [BlackBoxEvent:R-SSC-5635102] GPR161 is internalized - Sus scrofa [BlackBoxEvent:R-BTA-5635102] GPR161 is internalized - Bos taurus [BlackBoxEvent:R-CFA-5635102] GPR161 is internalized - Canis familiaris [BlackBoxEvent:R-RNO-5635102] GPR161 is internalized - Rattus norvegicus [BlackBoxEvent:R-MMU-5635102] GPR161 is internalized - Mus musculus
output	[EntityWithAccessionedSequence:R-HSA-5635021] GPR161 [endocytic vesicle membrane]
releaseDate	2014-12-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5636011] Liu, Yulu Cherry, 2014-11-09
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-5635102
summation	[Summation:5635100] Hh signaling promotes the removal of the orphan G protein co...

Referrals

(hasEvent)

[Pathway:R-HSA-5632684] Hedgehog 'on' state