Reactome | phosphorylated GLI proteins bind SPOP:CUL3:RBX1

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phosphorylated GLI proteins bind SPOP:CUL3:RBX1 Show undefined attributes

authored	[InstanceEdit:5633210] Rothfels, Karen, 2014-10-30
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5635857] Rothfels, Karen, 2014-11-07
dbId	5635855
displayName	phosphorylated GLI proteins bind SPOP:CUL3:RBX1
edited	[InstanceEdit:5633134] Gillespie, Marc E, 2014-10-30
eventOf	[Pathway:R-HSA-5632684] Hedgehog 'on' state - Homo sapiens
followingEvent	[Reaction:R-HSA-5635856] SPOP:CUL3:RBX1 ubiquitinates GLI2,3 - Homo sapiens
input	[DefinedSet:R-HSA-5635080] 2p-GLI2,3 [nucleoplasm] [Complex:R-HSA-5635071] SPOP:CUL3:RBX1 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5609873] The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins [LiteratureReference:5634917] Hedgehog stimulates maturation of Cubitus interruptus into a labile transcriptional activator [LiteratureReference:5609686] A mechanism for vertebrate Hedgehog signaling: recruitment to cilia and dissociation of SuFu-Gli protein complexes [LiteratureReference:5610143] Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved [LiteratureReference:5634936] Multiple Ser/Thr-rich degrons mediate the degradation of Ci/Gli by the Cul3-HIB/SPOP E3 ubiquitin ligase [LiteratureReference:5609775] Kinetics of hedgehog-dependent full-length Gli3 accumulation in primary cilia and subsequent degradation [LiteratureReference:216263] A hedgehog-induced BTB protein modulates hedgehog signaling by degrading Ci/Gli transcription factor [LiteratureReference:216191] Roadkill attenuates Hedgehog responses through degradation of Cubitus interruptus [LiteratureReference:976142] Targeting of protein ubiquitination by BTB-Cullin 3-Roc1 ubiquitin ligases [LiteratureReference:5634968] Structures of SPOP-substrate complexes: insights into molecular architectures of BTB-Cul3 ubiquitin ligases [LiteratureReference:5634996] The zebrafish iguana locus encodes Dzip1, a novel zinc-finger protein required for proper regulation of Hedgehog signaling [LiteratureReference:5635003] iguana encodes a novel zinc-finger protein with coiled-coil domains essential for Hedgehog signal transduction in the zebrafish embryo [LiteratureReference:5634981] The Zn finger protein Iguana impacts Hedgehog signaling by promoting ciliogenesis [LiteratureReference:5634910] Gli2a protein localization reveals a role for Iguana/DZIP1 in primary ciliogenesis and a dependence of Hedgehog signal transduction on primary cilia in the zebrafish [LiteratureReference:5634986] The iguana/DZIP1 protein is a novel component of the ciliogenic pathway essential for axonemal biogenesis [LiteratureReference:5634893] Centrosomal protein DZIP1 regulates Hedgehog signaling by promoting cytoplasmic retention of transcription factor GLI3 and affecting ciliogenesis [LiteratureReference:5634984] The antagonistic action of B56-containing protein phosphatase 2As and casein kinase 2 controls the phosphorylation and Gli turnover function of Daz interacting protein 1 [LiteratureReference:5634951] Stabilization of speckle-type POZ protein (Spop) by Daz interacting protein 1 (Dzip1) is essential for Gli turnover and the proper output of Hedgehog signaling
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	phosphorylated GLI proteins bind SPOP:CUL3:RBX1
orthologousEvent	[Reaction:R-DME-5635855] phosphorylated GLI proteins bind SPOP:CUL3:RBX1 - Drosophila melanogaster [Reaction:R-GGA-5635855] phosphorylated GLI proteins bind SPOP:CUL3:RBX1 - Gallus gallus [Reaction:R-XTR-5635855] phosphorylated GLI proteins bind SPOP:CUL3:RBX1 - Xenopus tropicalis [Reaction:R-DRE-5635855] phosphorylated GLI proteins bind SPOP:CUL3:RBX1 - Danio rerio [Reaction:R-BTA-5635855] phosphorylated GLI proteins bind SPOP:CUL3:RBX1 - Bos taurus [Reaction:R-RNO-5635855] phosphorylated GLI proteins bind SPOP:CUL3:RBX1 - Rattus norvegicus [Reaction:R-MMU-5635855] phosphorylated GLI proteins bind SPOP:CUL3:RBX1 - Mus musculus
output	[Complex:R-HSA-5635087] 2p-GLI:SPOP:CUL3:RBX1 [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-HSA-5635841] GLI proteins are phosphorylated - Homo sapiens
regulatedBy	[PositiveRegulation:R-HSA-5635873] Positive regulation by 'DZIP1 [nucleoplasm]'
releaseDate	2014-12-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5636011] Liu, Yulu Cherry, 2014-11-09
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5635855
summation	[Summation:5635805] Full-length GLI proteins are labile transcription factors th...

Referrals

(hasEvent)	[Pathway:R-HSA-5632684] Hedgehog 'on' state
(precedingEvent)	[Reaction:R-HSA-5635856] SPOP:CUL3:RBX1 ubiquitinates GLI2,3

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