Reactome | PCP/CE pathway

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PCP/CE pathway Show undefined attributes

authored	[InstanceEdit:4086399] Rothfels, K, 2013-08-07
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:4086399] Rothfels, K, 2013-08-07
dbId	4086400
displayName	PCP/CE pathway
edited	[InstanceEdit:4663813] Matthews, L, 2013-10-07
eventOf	[Pathway:R-HSA-3858494] Beta-catenin independent WNT signaling - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:261442] Wnt signaling pathway, planar cell polarity pathway
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-3858491] WNTs bind the FZD receptor to initiate PCP pathway - Homo sapiens [Reaction:R-HSA-3858482] DVL is recruited to the receptor - Homo sapiens [Reaction:R-HSA-3858480] WNT-dependent phosphorylation of DVL - Homo sapiens [Reaction:R-HSA-3858489] ppDVL binds DAAM1 - Homo sapiens [Reaction:R-HSA-3858495] DAAM1 recruits GTP-bound RHOA - Homo sapiens [Reaction:R-HSA-3858475] ppDVL recruits RAC - Homo sapiens [Reaction:R-HSA-3965450] DAAM1 recruits PFN1 - Homo sapiens [Reaction:R-HSA-4551555] RYK binds WNT5A and VANGL2 - Homo sapiens [Reaction:R-HSA-4551571] WNT5A binds ROR2 and VANGL2 - Homo sapiens [Reaction:R-HSA-4551570] VANGL2 is phosphorylated in response to WNT5A - Homo sapiens [Pathway:R-HSA-4608870] Asymmetric localization of PCP proteins - Homo sapiens [Pathway:R-HSA-5099900] WNT5A-dependent internalization of FZD4 - Homo sapiens [Pathway:R-HSA-5140745] WNT5A-dependent internalization of FZD2, FZD5 and ROR2 - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2020-03-16
literatureReference	[LiteratureReference:4551375] Planar cell polarity in Drosophila [LiteratureReference:4551415] Wnt regulation of planar cell polarity (PCP) [LiteratureReference:4551398] Silberblick/Wnt11 mediates convergent extension movements during zebrafish gastrulation [LiteratureReference:4551427] Wnt5 is required for tail formation in the zebrafish embryo [LiteratureReference:4551435] Wnt5a functions in planar cell polarity regulation in mice [LiteratureReference:3247726] Wnt/Fz signaling and the cytoskeleton: potential roles in tumorigenesis [LiteratureReference:3247724] Wnt signaling pathways meet Rho GTPases [LiteratureReference:4549494] Ryks: new partners for Wnts in the developing and regenerating nervous system [LiteratureReference:4551380] Ror receptor tyrosine kinases: orphans no more
maxDepth	3
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	PCP/CE pathway
orthologousEvent	[Pathway:R-CEL-4086400] PCP/CE pathway - Caenorhabditis elegans [Pathway:R-DME-4086400] PCP/CE pathway - Drosophila melanogaster [Pathway:R-GGA-4086400] PCP/CE pathway - Gallus gallus [Pathway:R-XTR-4086400] PCP/CE pathway - Xenopus tropicalis [Pathway:R-DRE-4086400] PCP/CE pathway - Danio rerio [Pathway:R-SSC-4086400] PCP/CE pathway - Sus scrofa [Pathway:R-BTA-4086400] PCP/CE pathway - Bos taurus [Pathway:R-CFA-4086400] PCP/CE pathway - Canis familiaris [Pathway:R-RNO-4086400] PCP/CE pathway - Rattus norvegicus [Pathway:R-MMU-4086400] PCP/CE pathway - Mus musculus
releaseDate	2013-12-04
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5099870] Kikuchi, Akira, 2013-11-12
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-4086400
summation	[Summation:4551564] The planar cell polarity (PCP) pathway controls the establis...
updateTrackers	[UpdateTracker:9786733] Update Tracker - [Pathway:4086400] PCP/CE pathway - v48:[updateContainedRLE, updateIndirectRLE] [UpdateTracker:9777217] Update Tracker - [Pathway:4086400] PCP/CE pathway - v72:[updateContainedRLE] [UpdateTracker:9782241] Update Tracker - [Pathway:4086400] PCP/CE pathway - v59:[updateIndirectRLE] [UpdateTracker:9785206] Update Tracker - [Pathway:4086400] PCP/CE pathway - v52:[updateContainedRLE] [UpdateTracker:9786431] Update Tracker - [Pathway:4086400] PCP/CE pathway - v49:[updateContainedPathway]

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[Pathway:R-HSA-3858494] Beta-catenin independent WNT signaling

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