Reactome | ppDVL recruits RAC

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ppDVL recruits RAC Show undefined attributes

authored	[InstanceEdit:3782517] Rothfels, K, 2013-06-28
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:3858488] Rothfels, K, 2013-07-09
dbId	3858475
displayName	ppDVL recruits RAC
edited	[InstanceEdit:4663813] Matthews, L, 2013-10-07
eventOf	[Pathway:R-HSA-4086400] PCP/CE pathway - Homo sapiens
input	[CandidateSet:R-HSA-3858467] pp-DVL [cytosol] [Complex:R-HSA-3858468] RAC:GTP [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:351078] Coactivation of Rac and Rho by Wnt/Frizzled signaling is required for vertebrate gastrulation [LiteratureReference:351112] Wnt/Frizzled activation of Rho regulates vertebrate gastrulation and requires a novel Formin homology protein Daam1 [LiteratureReference:3858403] JNK functions in the non-canonical Wnt pathway to regulate convergent extension movements in vertebrates [LiteratureReference:3858427] Wnt signaling through Dishevelled, Rac and JNK regulates dendritic development [LiteratureReference:3858412] Tiam1 regulates the Wnt/Dvl/Rac1 signaling pathway and the differentiation of midbrain dopaminergic neurons [LiteratureReference:3858398] Dishevelled activates JNK and discriminates between JNK pathways in planar polarity and wingless signaling [LiteratureReference:351094] Differential recruitment of Dishevelled provides signaling specificity in the planar cell polarity and Wingless signaling pathways [LiteratureReference:3965302] Mammalian Rho GTPases: new insights into their functions from in vivo studies [LiteratureReference:3247726] Wnt/Fz signaling and the cytoskeleton: potential roles in tumorigenesis
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	ppDVL recruits RAC
orthologousEvent	[Reaction:R-CEL-3858475] ppDVL recruits RAC - Caenorhabditis elegans [Reaction:R-DME-3858475] ppDVL recruits RAC - Drosophila melanogaster [Reaction:R-DRE-3858475] ppDVL recruits RAC - Danio rerio [Reaction:R-SSC-3858475] ppDVL recruits RAC - Sus scrofa [Reaction:R-CFA-3858475] ppDVL recruits RAC - Canis familiaris [Reaction:R-RNO-3858475] ppDVL recruits RAC - Rattus norvegicus [Reaction:R-MMU-3858475] ppDVL recruits RAC - Mus musculus
output	[Complex:R-HSA-3858469] pp-DVL:RAC:GTP [plasma membrane]
precedingEvent	[Reaction:R-HSA-3858480] WNT-dependent phosphorylation of DVL - Homo sapiens
releaseDate	2013-12-04
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5099870] Kikuchi, Akira, 2013-11-12
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-3858475
summation	[Summation:3858441] WNT-dependent activation of dishevelled proteins (DVL) induc...
updateTrackers	[UpdateTracker:9777170] Update Tracker - [Reaction:3858475] ppDVL recruits RAC - v72:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9777170] Update Tracker - [Reaction:3858475] ppDVL recruits RAC - v72:[modifyText]
(hasEvent)	[Pathway:R-HSA-4086400] PCP/CE pathway

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