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Entries
WNT5A-dependent internalization of FZD4
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authored
[InstanceEdit:5099870] Kikuchi, Akira, 2013-11-12
compartment
[Compartment:876] plasma membrane
[Compartment:70101] cytosol
[Compartment:984] extracellular region
[Compartment:20592] clathrin-coated endocytic vesicle
[Compartment:24339] clathrin-coated endocytic vesicle membrane
created
[InstanceEdit:5099902] Rothfels, K, 2013-11-13
crossReference
[DatabaseIdentifier:12325592] BioModels Database:BIOMD0000000842
dbId
5099900
displayName
WNT5A-dependent internalization of FZD4
edited
[InstanceEdit:5144530] Matthews, L, 2013-11-15
eventOf
[Pathway:R-HSA-4086400] PCP/CE pathway - Homo sapiens
hasDiagram
false
hasEHLD
false
hasEvent
[Reaction:R-HSA-5099899] WNT5A binds FZD4 - Homo sapiens
[Reaction:R-HSA-5138441] WNT5A-FZD4 recruits DVL2 - Homo sapiens
[Reaction:R-HSA-5138432] DVL2 is phosphorylated by PKC - Homo sapiens
[Reaction:R-HSA-5138433] p-DVL2 recruits AP-2 and beta-arrestin 2 to promote clathrin-mediated endocytosis - Homo sapiens
[BlackBoxEvent:R-HSA-5138459] WNT5A:FZD4 is endocytosed - Homo sapiens
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:5138420] Association of Dishevelled with the clathrin AP-2 adaptor is required for Frizzled endocytosis and planar cell polarity signaling
[LiteratureReference:5138423] Dishevelled 2 recruits beta-arrestin 2 to mediate Wnt5A-stimulated endocytosis of Frizzled 4
[LiteratureReference:5138424] Structural analysis of the interaction between Dishevelled2 and clathrin AP-2 adaptor, a critical step in noncanonical Wnt signaling
modified
[InstanceEdit:12325341] Wright, Adam, 2024-02-14
name
WNT5A-dependent internalization of FZD4
orthologousEvent
[Pathway:R-CEL-5099900] WNT5A-dependent internalization of FZD4 - Caenorhabditis elegans
[Pathway:R-DME-5099900] WNT5A-dependent internalization of FZD4 - Drosophila melanogaster
[Pathway:R-GGA-5099900] WNT5A-dependent internalization of FZD4 - Gallus gallus
[Pathway:R-XTR-5099900] WNT5A-dependent internalization of FZD4 - Xenopus tropicalis
[Pathway:R-SSC-5099900] WNT5A-dependent internalization of FZD4 - Sus scrofa
[Pathway:R-BTA-5099900] WNT5A-dependent internalization of FZD4 - Bos taurus
[Pathway:R-CFA-5099900] WNT5A-dependent internalization of FZD4 - Canis familiaris
[Pathway:R-RNO-5099900] WNT5A-dependent internalization of FZD4 - Rattus norvegicus
[Pathway:R-MMU-5099900] WNT5A-dependent internalization of FZD4 - Mus musculus
releaseDate
2013-12-04
reviewStatus
[ReviewStatus:9821382] five stars
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-5099900
summation
[Summation:5138464] WNT5A induces internalization of FZD4 in a manner that depen...
Referrals
(hasEvent)
[Pathway:R-HSA-4086400] PCP/CE pathway
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