Reactome | WNT-dependent phosphorylation of DVL

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WNT-dependent phosphorylation of DVL Show undefined attributes

authored	[InstanceEdit:3782517] Rothfels, K, 2013-06-28
catalystActivity	[CatalystActivity:5250906] protein serine/threonine kinase activity of unknown kinase [cytosol]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:3858488] Rothfels, K, 2013-07-09
dbId	3858480
displayName	WNT-dependent phosphorylation of DVL
edited	[InstanceEdit:4663813] Matthews, L, 2013-10-07
eventOf	[Pathway:R-HSA-4086400] PCP/CE pathway - Homo sapiens
followingEvent	[Reaction:R-HSA-3858475] ppDVL recruits RAC - Homo sapiens [Reaction:R-HSA-3858489] ppDVL binds DAAM1 - Homo sapiens
inferredFrom	[Reaction:R-NUL-3858478] Rat Dvl is phosophorylated upon Wnt binding - Mus musculus
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-3858484] WNT:FZD:pDVL [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:3858424] Wnt proteins induce dishevelled phosphorylation via an LRP5/6- independent mechanism, irrespective of their ability to stabilize beta-catenin [LiteratureReference:3772339] Dishevelled: The hub of Wnt signaling [LiteratureReference:5099861] Functional consequences of Wnt-induced dishevelled 2 phosphorylation in canonical and noncanonical Wnt signaling
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	WNT-dependent phosphorylation of DVL
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [CandidateSet:R-HSA-3858467] pp-DVL [cytosol] [Complex:R-HSA-3858486] WNT:FZD [plasma membrane]
precedingEvent	[Reaction:R-HSA-3858482] DVL is recruited to the receptor - Homo sapiens
releaseDate	2013-12-04
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5099870] Kikuchi, Akira, 2013-11-12
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-3858480
summation	[Summation:3858438] In response to WNT signaling, dishevelled (DVL) proteins are...
updateTrackers	[UpdateTracker:9777152] Update Tracker - [Reaction:3858480] WNT-dependent phosphorylation of DVL - v72:[modifyText] [UpdateTracker:9786822] Update Tracker - [Reaction:3858480] WNT-dependent phosphorylation of DVL - v48:[add_removeCatalystActivity]

Referrals

(updatedInstance)	[UpdateTracker:9777152] Update Tracker - [Reaction:3858480] WNT-dependent phosphorylation of DVL - v72:[modifyText] [UpdateTracker:9786822] Update Tracker - [Reaction:3858480] WNT-dependent phosphorylation of DVL - v48:[add_removeCatalystActivity]
(precedingEvent)	[Reaction:R-HSA-3858475] ppDVL recruits RAC [Reaction:R-HSA-3858489] ppDVL binds DAAM1 [NegativePrecedingEvent:9864365] Futile Cycle: WNT-dependent phosphorylation of DVL
(hasEvent)	[Pathway:R-HSA-4086400] PCP/CE pathway
(inferredTo)	[Reaction:R-NUL-3858478] Rat Dvl is phosophorylated upon Wnt binding