Reactome | Asymmetric localization of PCP proteins

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Asymmetric localization of PCP proteins Show undefined attributes

authored	[InstanceEdit:4568841] Rothfels, K, 2013-09-18
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:4608869] Rothfels, K, 2013-09-23
dbId	4608870
displayName	Asymmetric localization of PCP proteins
edited	[InstanceEdit:4663813] Matthews, L, 2013-10-07
eventOf	[Pathway:R-HSA-4086400] PCP/CE pathway - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-4608862] SCRIB is required for asymmetric membrane localization of VANGL2 - Homo sapiens [Reaction:R-HSA-4608866] VANGL2 is required for asymmetric membrane localization of FZD3 - Homo sapiens [Reaction:R-HSA-5099886] WNT5A binding to FZD promotes PRICKLE1 degradation - Homo sapiens [Reaction:R-HSA-4608825] DVL2 is phosphorylated after WNT5A binding to FZD - Homo sapiens [Reaction:R-HSA-4608854] SMURF1/2 are recruited to the DVL2:PARD6A complex - Homo sapiens [Reaction:R-HSA-4608852] SMURF1/2 ubiquitinates PRICKLE1 - Homo sapiens [BlackBoxEvent:R-HSA-4608855] PRICKLE1 is degraded by the proteasome - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2016-12-21
literatureReference	[LiteratureReference:350987] Frizzled/PCP signalling: a conserved mechanism regulating cell polarity and directed motility [LiteratureReference:4608822] Asymmetric localization of Vangl2 and Fz3 indicate novel mechanisms for planar cell polarity in mammals [LiteratureReference:4608844] Identification of Vangl2 and Scrb1 as planar polarity genes in mammals [LiteratureReference:4568829] The role of Frizzled3 and Frizzled6 in neural tube closure and in the planar polarity of inner-ear sensory hair cells [LiteratureReference:4608829] Regulation of planar cell polarity by Smurf ubiquitin ligases
maxDepth	2
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Asymmetric localization of PCP proteins
orthologousEvent	[Pathway:R-CEL-4608870] Asymmetric localization of PCP proteins - Caenorhabditis elegans [Pathway:R-DME-4608870] Asymmetric localization of PCP proteins - Drosophila melanogaster [Pathway:R-GGA-4608870] Asymmetric localization of PCP proteins - Gallus gallus [Pathway:R-XTR-4608870] Asymmetric localization of PCP proteins - Xenopus tropicalis [Pathway:R-DRE-4608870] Asymmetric localization of PCP proteins - Danio rerio [Pathway:R-SSC-4608870] Asymmetric localization of PCP proteins - Sus scrofa [Pathway:R-BTA-4608870] Asymmetric localization of PCP proteins - Bos taurus [Pathway:R-CFA-4608870] Asymmetric localization of PCP proteins - Canis familiaris [Pathway:R-RNO-4608870] Asymmetric localization of PCP proteins - Rattus norvegicus [Pathway:R-MMU-4608870] Asymmetric localization of PCP proteins - Mus musculus
releaseDate	2013-12-04
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5099870] Kikuchi, Akira, 2013-11-12
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-4608870
summation	[Summation:4608848] One of the hallmarks of the Planar Cell Polarity pathway is ...
updateTrackers	[UpdateTracker:9786784] Update Tracker - [Pathway:4608870] Asymmetric localization of PCP proteins - v48:[updateContainedRLE] [UpdateTracker:9786525] Update Tracker - [Pathway:4608870] Asymmetric localization of PCP proteins - v49:[addHasEvent] [UpdateTracker:9782587] Update Tracker - [Pathway:4608870] Asymmetric localization of PCP proteins - v59:[updateContainedRLE]

Referrals

(updatedInstance)	[UpdateTracker:9786784] Update Tracker - [Pathway:4608870] Asymmetric localization of PCP proteins - v48:[updateContainedRLE] [UpdateTracker:9786525] Update Tracker - [Pathway:4608870] Asymmetric localization of PCP proteins - v49:[addHasEvent] [UpdateTracker:9782587] Update Tracker - [Pathway:4608870] Asymmetric localization of PCP proteins - v59:[updateContainedRLE]
(hasEvent)	[Pathway:R-HSA-4086400] PCP/CE pathway

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