Reactome | WNT5A binds ROR2 and VANGL2

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WNT5A binds ROR2 and VANGL2 Show undefined attributes

authored	[InstanceEdit:4549500] Rothfels, K, 2013-09-12
category	binding
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:4551569] Rothfels, K, 2013-09-13
dbId	4551571
displayName	WNT5A binds ROR2 and VANGL2
edited	[InstanceEdit:4663813] Matthews, L, 2013-10-07
eventOf	[Pathway:R-HSA-4086400] PCP/CE pathway - Homo sapiens
followingEvent	[Reaction:R-HSA-4551570] VANGL2 is phosphorylated in response to WNT5A - Homo sapiens
inferredFrom	[Reaction:R-MMU-4551566] Wnt5a binds Ror2 and Vangl2 - Mus musculus
input	[EntityWithAccessionedSequence:R-HSA-3247777] N4GlycoAsn-PalmS WNT5A(36-380) [extracellular region] [EntityWithAccessionedSequence:R-HSA-197731] ROR2 [plasma membrane] [EntityWithAccessionedSequence:R-HSA-3965373] VANGL2 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:4551418] Wnt signaling gradients establish planar cell polarity by inducing Vangl2 phosphorylation through Ror2 [LiteratureReference:3247727] Ror-family receptor tyrosine kinases in noncanonical Wnt signaling: their implications in developmental morphogenesis and human diseases [LiteratureReference:4551410] The receptor tyrosine kinase Ror2 is involved in non-canonical Wnt5a/JNK signalling pathway [LiteratureReference:517399] Purified Wnt5a protein activates or inhibits beta-catenin-TCF signaling depending on receptor context [LiteratureReference:4551391] Ror2 modulates the canonical Wnt signaling in lung epithelial cells through cooperation with Fzd2
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	WNT5A binds ROR2 and VANGL2
output	[Complex:R-HSA-4551543] N4GlycoAsn-PalmS WNT5A:ROR2:VANGL2 [plasma membrane]
precedingEvent	[Reaction:R-HSA-3247843] secretion of WNT ligands - Homo sapiens
releaseDate	2013-12-04
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5099870] Kikuchi, Akira, 2013-11-12
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-4551571
summation	[Summation:4551567] WNT5A binds ROR2 and VANGL2 to promote PCP in mouse limb bud...

Referrals

(precedingEvent)	[Reaction:R-HSA-4551570] VANGL2 is phosphorylated in response to WNT5A
(hasEvent)	[Pathway:R-HSA-4086400] PCP/CE pathway
(inferredTo)	[Reaction:R-MMU-4551566] Wnt5a binds Ror2 and Vangl2