Reactome | DVL is recruited to the receptor

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DVL is recruited to the receptor Show undefined attributes

authored	[InstanceEdit:3782517] Rothfels, K, 2013-06-28
category	binding
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:3858488] Rothfels, K, 2013-07-09
dbId	3858482
displayName	DVL is recruited to the receptor
edited	[InstanceEdit:4663813] Matthews, L, 2013-10-07
eventOf	[Pathway:R-HSA-4086400] PCP/CE pathway - Homo sapiens
followingEvent	[Reaction:R-HSA-3858480] WNT-dependent phosphorylation of DVL - Homo sapiens
input	[CandidateSet:R-HSA-3858479] p-DVL [cytosol] [Complex:R-HSA-3858486] WNT:FZD [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:3858398] Dishevelled activates JNK and discriminates between JNK pathways in planar polarity and wingless signaling [LiteratureReference:351094] Differential recruitment of Dishevelled provides signaling specificity in the planar cell polarity and Wingless signaling pathways [LiteratureReference:208130] Direct binding of the PDZ domain of Dishevelled to a conserved internal sequence in the C-terminal region of Frizzled [LiteratureReference:3965300] Gpr125 modulates Dishevelled distribution and planar cell polarity signaling [LiteratureReference:350958] Prickle mediates feedback amplification to generate asymmetric planar cell polarity signaling [LiteratureReference:3965326] Unipolar membrane association of Dishevelled mediates Frizzled planar cell polarity signaling [LiteratureReference:3772336] Dishevelled phosphorylation, subcellular localization and multimerization regulate its role in early embryogenesis [LiteratureReference:3965314] Structural basis of the recognition of the dishevelled DEP domain in the Wnt signaling pathway [LiteratureReference:3965315] Subcellular localization and signaling properties of dishevelled in developing vertebrate embryos [LiteratureReference:3965331] Wnt11 controls cell contact persistence by local accumulation of Frizzled 7 at the plasma membrane [LiteratureReference:3965342] XRab40 and XCullin5 form a ubiquitin ligase complex essential for the noncanonical Wnt pathway
modified	[InstanceEdit:10740525] Wright, Adam, 2024-03-08
name	DVL is recruited to the receptor
orthologousEvent	[Reaction:R-CEL-3858482] DVL is recruited to the receptor - Caenorhabditis elegans [Reaction:R-DME-3858482] DVL is recruited to the receptor - Drosophila melanogaster [Reaction:R-XTR-3858482] DVL is recruited to the receptor - Xenopus tropicalis [Reaction:R-DRE-3858482] DVL is recruited to the receptor - Danio rerio [Reaction:R-SSC-3858482] DVL is recruited to the receptor - Sus scrofa [Reaction:R-BTA-3858482] DVL is recruited to the receptor - Bos taurus [Reaction:R-CFA-3858482] DVL is recruited to the receptor - Canis familiaris [Reaction:R-RNO-3858482] DVL is recruited to the receptor - Rattus norvegicus [Reaction:R-MMU-3858482] DVL is recruited to the receptor - Mus musculus
output	[Complex:R-HSA-3858484] WNT:FZD:pDVL [plasma membrane]
precedingEvent	[Reaction:R-HSA-3858491] WNTs bind the FZD receptor to initiate PCP pathway - Homo sapiens
releaseDate	2013-12-04
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5099870] Kikuchi, Akira, 2013-11-12
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-3858482
summation	[Summation:3965347] The DEP domain of dishevelled proteins (DVL) is required bot...

Referrals

(hasEvent)	[Pathway:R-HSA-4086400] PCP/CE pathway
(precedingEvent)	[Reaction:R-HSA-3858480] WNT-dependent phosphorylation of DVL

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